Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

被引：21

作者：

Waisertreiger, Irina S. -R. ^{[1
]}

Liston, Victoria G. ^{[1
]}

Menezes, Miriam R. ^{[1
]}

Kim, Hyun-Min ^{[2
,3
]}

Lobachev, Kirill S. ^{[2
,3
]}

Stepchenkova, Elena I. ^{[1
,4
,5
]}

Tahirov, Tahir H. ^{[1
]}

Rogozin, Igor B. ^{[6
,7
]}

Pavlov, Youri I. ^{[1
,5
]}

机构：

[1] Univ Nebraska, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68182 USA

[2] Georgia Inst Technol, Sch Biol, Dept Bil, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[4] Vavilov Inst Gen Genet, St Petersburg Branch, Lab Modeling Human Dis, St Petersburg 199034, Russia

[5] St Petersburg Univ, Dept Genet, St Petersburg 199034, Russia

[6] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA

[7] Russian Acad Sci, Inst Cytol & Genet, Mutagenesis Sect, Novosibirsk 630090, Russia

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2012年 / 53卷 / 09期

基金：

美国国家卫生研究院;

关键词：

DNA polymerases; nucleotide pools; mutagenesis; Okazaki fragments; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; BASE ANALOG 6-N-HYDROXYLAMINOPURINE; POLYMERASE ALPHA-PRIMASE; CELL NUCLEAR ANTIGEN; HUMAN MISMATCH REPAIR; STRAND-BREAK-REPAIR; DAMAGE-INDUCED MUTAGENESIS; UNIQUE ERROR SIGNATURE; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI;

D O I：

10.1002/em.21735

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti-parallel strands of duplex DNA occurs through the copying of leading and lagging strand templates by a trio of Pols alpha, delta and epsilon, with the assistance of Pol xi and Y-family Pols at difficult DNA template structures or sites of DNA damage. The parameters of the synthesis at a given location are dictated by the quality and quantity of nucleotides in the pools, replication fork architecture, transcription status, regulation of Pol switches, and structure of chromatin. The result of these transactions is a subject of survey and editing by DNA repair. Environ. Mol. Mutagen., 2012. (c) 2012 Wiley Periodicals, Inc.

引用

页码：699 / 724

页数：26

共 36 条

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[32] A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA
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[35] Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork
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[36] STAG2 Loss Gives Rise to Therapeutically Targetable DNA Damage Repair Defects and Altered Replication Fork Dynamics in Acute Myeloid Leukaemia
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