Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools

被引：21

作者：

Waisertreiger, Irina S. -R. ^{[1
]}

Liston, Victoria G. ^{[1
]}

Menezes, Miriam R. ^{[1
]}

Kim, Hyun-Min ^{[2
,3
]}

Lobachev, Kirill S. ^{[2
,3
]}

Stepchenkova, Elena I. ^{[1
,4
,5
]}

Tahirov, Tahir H. ^{[1
]}

Rogozin, Igor B. ^{[6
,7
]}

Pavlov, Youri I. ^{[1
,5
]}

机构：

[1] Univ Nebraska, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68182 USA

[2] Georgia Inst Technol, Sch Biol, Dept Bil, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[4] Vavilov Inst Gen Genet, St Petersburg Branch, Lab Modeling Human Dis, St Petersburg 199034, Russia

[5] St Petersburg Univ, Dept Genet, St Petersburg 199034, Russia

[6] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA

[7] Russian Acad Sci, Inst Cytol & Genet, Mutagenesis Sect, Novosibirsk 630090, Russia

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2012年 / 53卷 / 09期

基金：

美国国家卫生研究院;

关键词：

DNA polymerases; nucleotide pools; mutagenesis; Okazaki fragments; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; BASE ANALOG 6-N-HYDROXYLAMINOPURINE; POLYMERASE ALPHA-PRIMASE; CELL NUCLEAR ANTIGEN; HUMAN MISMATCH REPAIR; STRAND-BREAK-REPAIR; DAMAGE-INDUCED MUTAGENESIS; UNIQUE ERROR SIGNATURE; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI;

D O I：

10.1002/em.21735

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The rate of mutations in eukaryotes depends on a plethora of factors and is not immediately derived from the fidelity of DNA polymerases (Pols). Replication of chromosomes containing the anti-parallel strands of duplex DNA occurs through the copying of leading and lagging strand templates by a trio of Pols alpha, delta and epsilon, with the assistance of Pol xi and Y-family Pols at difficult DNA template structures or sites of DNA damage. The parameters of the synthesis at a given location are dictated by the quality and quantity of nucleotides in the pools, replication fork architecture, transcription status, regulation of Pol switches, and structure of chromatin. The result of these transactions is a subject of survey and editing by DNA repair. Environ. Mol. Mutagen., 2012. (c) 2012 Wiley Periodicals, Inc.

引用

页码：699 / 724

页数：26

共 36 条

[21] Single-Molecule Studies of Fork Dynamics in E. coli DNA Replication
Tanner, Nathan A.
BIOPHYSICAL JOURNAL, 2009, 96 (03) : 342A - 342A
[22] Erratum: Single-molecule studies of fork dynamics in Escherichia coli DNA replication
Nathan A Tanner
Samir M Hamdan
Slobodan Jergic
Karin V Loscha
Patrick M Schaeffer
Nicholas E Dixon
Antoine M van Oijen
Nature Structural & Molecular Biology, 2008, 15 : 998 - 998
[23] CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis
Chen, Lu
Zhou, Weichen
Zhang, Cheng
Lupski, James R.
Jin, Li
Zhang, Feng
HUMAN MOLECULAR GENETICS, 2015, 24 (06) : 1574 - 1583
[24] FIDELITY OF DNA-REPLICATION - EFFECT OF DIVALENT METAL-ION ACTIVATORS AND DEOXYRIBONUCLEOSIDE TRIPHOSPHATE POOLS ON INVITRO MUTAGENESIS
KUNKEL, TA
LOEB, LA
JOURNAL OF BIOLOGICAL CHEMISTRY, 1979, 254 (13) : 5718 - 5725
[25] IDENTIFYING SITES OF SIMULTANEOUS DNA-REPLICATION IN EUKARYOTES BY N-METHYL-N'-NITROSOGUANIDINE-N-NITROSOGUANIDINE MULTIPLE MUTAGENESIS
DAWES, IW
MACKINNON, DA
BALL, DE
HARDIE, ID
SWEET, DM
ROSS, FM
MACDONALD, F
MOLECULAR & GENERAL GENETICS, 1977, 152 (01): : 53 - 57
[26] Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Constance Alabert
Jimi-Carlo Bukowski-Wills
Sung-Bau Lee
Georg Kustatscher
Kyosuke Nakamura
Flavia de Lima Alves
Patrice Menard
Jakob Mejlvang
Juri Rappsilber
Anja Groth
Nature Cell Biology, 2014, 16 : 281 - 291
[27] Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Alabert, Constance
Bukowski-Wills, Jimi-Carlo
Lee, Sung-Bau
Kustatscher, Georg
Nakamura, Kyosuke
Alves, Flavia de Lima
Menard, Patrice
Mejlvang, Jakob
Rappsilber, Juri
Groth, Anja
NATURE CELL BIOLOGY, 2014, 16 (03) : 281 - +
[28] The effect of tautomeric constant on the specificity of nucleotide incorporation during DNA replication: Support for the rare tautomer hypothesis of substitution mutagenesis
Harris, VH
Smith, CL
Cummins, WJ
Hamilton, AL
Adams, H
Dickman, M
Hornby, DP
Williams, DM
JOURNAL OF MOLECULAR BIOLOGY, 2003, 326 (05) : 1389 - 1401
[29] Single-molecule studies of fork dynamics in Escherichia coli DNA replication (vol 15, pg 170, 2008)
Tanner, Nathan A.
Hamdan, Samir M.
Jergic, Slobodan
Loscha, Karin V.
Schaeffer, Patrick M.
Dixon, Nicholas E.
van Oijen, Antoine M.
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (09) : 998 - 998
[30] DNA fiber combing protocol using in-house reagents and coverslips to analyze replication fork dynamics in mammalian cells
Moore, Gemma
Sainz, Judit Jimenez
Jensen, Ryan B.
STAR PROTOCOLS, 2022, 3 (02):

← 1 2 3 4 →