Multilayered Polymer-Coated Carbon Nanotubes To Deliver Dasatinib

被引：33

作者：

Moore, Thomas L. ^{[1
]}

Grimes, Stuart W. ^{[1
]}

Lewis, Robert L. ^{[1
]}

Alexis, Frank ^{[1
]}

机构：

[1] Clemson Univ, Dept Bioengn, Clemson, SC 29634 USA

来源：

MOLECULAR PHARMACEUTICS | 2014年 / 11卷 / 01期

关键词：

multilayered polymer coatings; carbon nanotube; synthesis; encapsulation; RING-OPENING POLYMERIZATION; RELEASE; BURST;

D O I：

10.1021/mp400448w

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-fimctionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

引用

页码：276 / 282

页数：7

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