Multilayered Polymer-Coated Carbon Nanotubes To Deliver Dasatinib

被引：33
|
作者：
Moore, Thomas L. [1 ]
Grimes, Stuart W. [1 ]
Lewis, Robert L. [1 ]
Alexis, Frank [1 ]
机构：
[1] Clemson Univ, Dept Bioengn, Clemson, SC 29634 USA
来源：
MOLECULAR PHARMACEUTICS | 2014年 / 11卷 / 01期
关键词：
multilayered polymer coatings; carbon nanotube; synthesis; encapsulation; RING-OPENING POLYMERIZATION; RELEASE; BURST;
D O I：
10.1021/mp400448w
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-fimctionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.
引用
收藏
页码：276 / 282
页数：7
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