Enzymatic synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid using serinehydroxymethyltransferase

被引：5
|
作者：
Miller, MJ
Richardson, SK
机构：
[1] Dept. of Chemistry and Biochemistry, University of Notre Dame, Notre Dame
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1996年 / 1卷 / 3-6期
关键词：
serinehydroxymethyltransferase; amino acids; aldol reaction; beta-lactams;
D O I：
10.1016/1381-1177(95)00022-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The scale up of earlier work from these laboratories using, the enzyme serinehydroxymethyltransferase has resulted in the use of this enzyme for the synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid (7) on a preparative scale. This compound, which has been barely described in the literature, is potentially useful for the synthesis of carbocyclic beta-lactams and carbocyclic nucleosides.
引用
收藏
页码：161 / 164
页数：4
相关论文
共 50 条
  • [41] Enantioselective synthesis of (2S,3R)-3-hydroxy-3-methylproline, a novel amino acid found in polyoxypeptins
    Qin, DG
    Zha, HY
    Yao, ZJ
    JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (03): : 1038 - 1040
  • [42] SYNTHESIS OF "4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID - AMINE COMPONENT OF PEPSTATIN
    MORISHIMA, H
    TAKITA, T
    UMEZAWA, H
    JOURNAL OF ANTIBIOTICS, 1973, 26 (02): : 115 - 116
  • [43] SYNTHESIS OF "4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID BY A MODIFIED REFORMATSKY REACTION
    LIU, WS
    GLOVER, GI
    JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (04): : 754 - 755
  • [44] (R)-2-hydroxy-3-triphenylmethylthiopropanoic acid, an intermediate in the synthesis of hydroxy analogs of oxytocin
    Wisniewski, K
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1999, 31 (02) : 211 - 214
  • [45] ELECTROCHEMICAL SYNTHESIS OF 2-ACETOXY-2-AMINO ACID AND 3-ACETOXY-3-AMINO ACID-DERIVATIVES
    IWASAKI, T
    HORIKAWA, H
    MATSUMOTO, K
    MIYOSHI, M
    JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (14): : 2419 - 2423
  • [46] CONVENIENT SYNTHESIS OF 2-SUBSTITUTED 3-HYDROXY-THIOPHENS AND 3-AMINO-THIOPHENS FROM DERIVATIVES OF 2-CHLOROACRYLIC ACID
    HUDDLESTON, PR
    BARKER, JM
    SYNTHETIC COMMUNICATIONS, 1979, 9 (08) : 731 - 734
  • [47] Iodolactonization of 3-amino-4-pentenoic acid:: a stereoselective synthesis of syn-γ-hydroxy-β-amino acids
    Delle Monache, G
    Misiti, D
    Salvatore, P
    Zappia, G
    TETRAHEDRON-ASYMMETRY, 2000, 11 (05) : 1137 - 1149
  • [48] ENZYMATIC SYNTHESIS OF DIPEPTIDE, TRP-HIS USING L-AMINO ACID ESTERASE
    Maki, K.
    Tanaka, T.
    Takagi, K.
    Wakayama, M.
    JOURNAL OF PEPTIDE SCIENCE, 2016, 22 : S224 - S224
  • [49] ENZYMATIC-SYNTHESIS OF L-BETA-CHLOROALANINE USING AMINO-ACID DEHYDROGENASE
    KATO, Y
    FUKUMOTO, K
    ASANO, Y
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1993, 39 (03) : 301 - 304
  • [50] ENZYMATIC SYNTHESIS OF DIPEPTIDE, VALYL-GLYCINE USING L-AMINO ACID ESTERASE
    Tanaka, T.
    Takagi, K.
    Wakayama, M.
    JOURNAL OF PEPTIDE SCIENCE, 2016, 22 : S224 - S224
12345