Enzymatic synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid using serinehydroxymethyltransferase

被引：5
|
作者：
Miller, MJ
Richardson, SK
机构：
[1] Dept. of Chemistry and Biochemistry, University of Notre Dame, Notre Dame
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1996年 / 1卷 / 3-6期
关键词：
serinehydroxymethyltransferase; amino acids; aldol reaction; beta-lactams;
D O I：
10.1016/1381-1177(95)00022-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The scale up of earlier work from these laboratories using, the enzyme serinehydroxymethyltransferase has resulted in the use of this enzyme for the synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid (7) on a preparative scale. This compound, which has been barely described in the literature, is potentially useful for the synthesis of carbocyclic beta-lactams and carbocyclic nucleosides.
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页码：161 / 164
页数：4
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