Enzymatic synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid using serinehydroxymethyltransferase

被引：5

作者：

Miller, MJ

Richardson, SK

机构：

[1] Dept. of Chemistry and Biochemistry, University of Notre Dame, Notre Dame

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1996年 / 1卷 / 3-6期

关键词：

serinehydroxymethyltransferase; amino acids; aldol reaction; beta-lactams;

D O I：

10.1016/1381-1177(95)00022-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The scale up of earlier work from these laboratories using, the enzyme serinehydroxymethyltransferase has resulted in the use of this enzyme for the synthesis of 2-amino-3-hydroxy-1,6-hexanedicarboxylic acid (7) on a preparative scale. This compound, which has been barely described in the literature, is potentially useful for the synthesis of carbocyclic beta-lactams and carbocyclic nucleosides.

引用

页码：161 / 164

页数：4

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