TBHP/NH4I-Mediated Direct N-H Phosphorylation of Imines and Imidates

被引：19
|
作者：
Wang, Xiaofeng [1 ]
Ou, Yingcong [1 ]
Peng, Zhenbo [2 ]
Yu, Guodian [1 ]
Huang, Yuanting [1 ]
Li, Xianwei [1 ]
Huo, Yanping [1 ]
Chen, Qian [1 ,3 ]
机构：
[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China
[2] Ningbo Polytech, Chem Engn Coll, Ningbo 315800, Zhejiang, Peoples R China
[3] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 22期
关键词：
DEHYDROGENATIVE COUPLING REACTION; PHOSPHINIC AMIDES; ASYMMETRIC-SYNTHESIS; EFFICIENT; BONDS; FUNCTIONALIZATION; SULFONYLATION; PHOSPHONATES; AMINES; THIOLS;
D O I：
10.1021/acs.joc.9b02301
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct and practical metal-free N-H phosphorylation has been achieved via the TBHP/NH4-Imediated cross-dehydrogenative coupling (CDC) reactions between imines/imidates and P(O)H compounds. This transformation provides an efficient synthetic route to the construction of P-N bonds with good functional group compatibility, leading to the formation of N-phosphorylimines and N-phosphorylimidates in up to 95% yield (33 examples) under mild conditions.
引用
收藏
页码：14949 / 14956
页数：8
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