Antivirals against (Re)emerging Flaviviruses: Should We Target the Virus or the Host?

被引：11

作者：

Perez-Perez, Maria-Jesus ^{[1
]}

Saiz, Juan-Carlos ^{[2
]}

Priego, Eva-Maria ^{[1
]}

Martin-Acebes, Miguel A. ^{[2
]}

机构：

[1] CSIC, Inst Quim Med IQM, E-28006 Madrid, Spain

[2] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotecnol, Madrid 28040, Spain

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2022年 / 13卷 / 01期

关键词：

flavivirus; virus-targeting; host-targeting; emerging virus; DENGUE;

D O I：

10.1021/acsmedchemlett.1c00617

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The COVID pandemic has evidenced how vulnerable we are to emerging infectious diseases and how short our current armamentarium is. Flavivirus, single stranded RNA viruses transmitted by arthropods, are considered a global health challenge. No drugs to treat these infections have been approved. In this Viewpoint, we analyze the advantages and disadvantages of two different, but probably also complementary, therapeutic approaches: virus-targeting antivirals and host-targeting drugs.

引用

页码：5 / 10

页数：6