Antivirals against (Re)emerging Flaviviruses: Should We Target the Virus or the Host?

被引：11
|
作者：
Perez-Perez, Maria-Jesus [1 ]
Saiz, Juan-Carlos [2 ]
Priego, Eva-Maria [1 ]
Martin-Acebes, Miguel A. [2 ]
机构：
[1] CSIC, Inst Quim Med IQM, E-28006 Madrid, Spain
[2] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotecnol, Madrid 28040, Spain
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2022年 / 13卷 / 01期
关键词：
flavivirus; virus-targeting; host-targeting; emerging virus; DENGUE;
D O I：
10.1021/acsmedchemlett.1c00617
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The COVID pandemic has evidenced how vulnerable we are to emerging infectious diseases and how short our current armamentarium is. Flavivirus, single stranded RNA viruses transmitted by arthropods, are considered a global health challenge. No drugs to treat these infections have been approved. In this Viewpoint, we analyze the advantages and disadvantages of two different, but probably also complementary, therapeutic approaches: virus-targeting antivirals and host-targeting drugs.
引用
收藏
页码：5 / 10
页数：6
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