Antivirals against (Re)emerging Flaviviruses: Should We Target the Virus or the Host?

被引：11
|
作者：
Perez-Perez, Maria-Jesus [1 ]
Saiz, Juan-Carlos [2 ]
Priego, Eva-Maria [1 ]
Martin-Acebes, Miguel A. [2 ]
机构：
[1] CSIC, Inst Quim Med IQM, E-28006 Madrid, Spain
[2] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotecnol, Madrid 28040, Spain
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2022年 / 13卷 / 01期
关键词：
flavivirus; virus-targeting; host-targeting; emerging virus; DENGUE;
D O I：
10.1021/acsmedchemlett.1c00617
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The COVID pandemic has evidenced how vulnerable we are to emerging infectious diseases and how short our current armamentarium is. Flavivirus, single stranded RNA viruses transmitted by arthropods, are considered a global health challenge. No drugs to treat these infections have been approved. In this Viewpoint, we analyze the advantages and disadvantages of two different, but probably also complementary, therapeutic approaches: virus-targeting antivirals and host-targeting drugs.
引用
收藏
页码：5 / 10
页数：6
相关论文
共 31 条
  • [1] Broad-spectrum antiviral strategy: Host-targeting antivirals against emerging and re-emerging viruses
    He, Yong
    Zhou, Jiahui
    Gao, Huizhan
    Liu, Chuanfeng
    Zhan, Peng
    Liu, Xinyong
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 265
  • [2] Antivirals that target the host IMPα/β1-virus interface
    Martin, Alexander J.
    Jans, David A.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2021, 49 (01) : 281 - 295
  • [3] A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses
    Zheng, Yucheng
    Li, Shiliang
    Song, Kun
    Ye, Jiajie
    Li, Wenkang
    Zhong, Yifan
    Feng, Ziyan
    Liang, Simeng
    Cai, Zeng
    Xu, Ke
    VIRUSES-BASEL, 2022, 14 (05):
  • [4] A Novel Target and Approach for Identifying Antivirals against Molluscum Contagiosum Virus
    Guan, Hancheng
    Nuth, Manunya
    Zhukovskaya, Natalia
    Saw, Yih Ling
    Bell, Edward
    Isaacs, Stuart N.
    Ricciardi, Robert P.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (12) : 7383 - 7389
  • [5] Emerging Zika virus infection:What should we know?
    Viroj Wiwanitkit
    Asian Pacific Journal of Tropical Biomedicine, 2016, (07) : 551 - 553
  • [6] Emerging Zika virus infection: What should we know?
    Wiwanitkit, Viroj
    ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, 2016, 6 (07) : 551 - 553
  • [7] Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus
    Kanda, Tatsuo
    Nakamoto, Shingo
    Wu, Shuang
    Nakamura, Masato
    Jiang, Xia
    Haga, Yuki
    Sasaki, Reina
    Yokosuka, Osamu
    JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2015, 3 (03) : 205 - 210
  • [8] Cellular Pathogenesis of Bluetongue Virus: Should we be Looking at the Host or the Insect Vector?
    Monaghan, Paul
    Darpel, Karin
    Shaw, Andrew
    Green, Dianne
    Adams, Mat
    Walker, Peter
    ECOHEALTH, 2011, 7 : S35 - S36
  • [9] Should We Vaccinate Healthcare Workers Against Respiratory Syncytial Virus?
    Faico-Filho, Klinger Soares
    Sita Perosa, Ana Helena
    Bellei, Nancy
    INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2024, 18 (08)
  • [10] RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections
    Yong, Hui Yee
    Luo, Dahai
    FRONTIERS IN IMMUNOLOGY, 2018, 9
1234