Guadinomines, Type III secretion system inhibitors, produced by streptomyces sp K01-0509

被引：41

作者：

Iwatsuki, Masato ^{[2
]}

Uchida, Ryuji ^{[2
]}

Yoshijima, Hitomi ^{[1
]}

Ui, Hideaki ^{[1
]}

Shiomi, Kazuro ^{[1
]}

Kim, Yong-Pil ^{[2
]}

Hirose, Tomoyasu ^{[2
]}

Sunazuka, Toshiaki ^{[1
]}

Abe, Akio ^{[1
]}

Tomoda, Hiroshi ^{[1
]}

Omura, Satoshi ^{[1
,2
]}

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 04期

关键词：

guadinomines; Type III secretion system; Streptomyces sp K01-0509; EPEC;

D O I：

10.1038/ja.2008.33

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. KOI-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C-1, C-2 and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.

引用

页码：230 / 236

页数：7

共 50 条

[31] New bioactive secondary metabolites from the soil-derived Streptomyces sp. S045 and their anti-bacterial and anti-type III secretion system activities
Zhang, Xiaochun
Song, Yuliang
Zhang, Zhiqiang
Lu, Chunhua
Shen, Yuemao
NATURAL PRODUCT RESEARCH, 2024,
[32] Vibrio parahaemolyticus Senses Intracellular K+ To Translocate Type III Secretion System 2 Effectors Effectively
Tandhavanant, Sarunporn
Matsuda, Shigeaki
Hiyoshi, Hirotaka
Iida, Tetsuya
Kodama, Toshio
MBIO, 2018, 9 (04):
[33] Developing Cyclic Peptomers as Broad-Spectrum Type III Secretion System Inhibitors in Gram-Negative Bacteria
Lam, Hanh N.
Lau, Tannia
Lentz, Adam
Sherry, Jessica
Cabrera-Cortez, Alejandro
Hug, Karen
Lalljie, Annalyse
Engel, Joanne
Lokey, R. Scott
Auerbuch, Victoria
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (07)
[34] Design and Synthesis of Aryl Amide Derivatives Containing Thiazole as Type III Secretion System Inhibitors against Pseudomonas aeruginosa
Guan, Mingming
Zhu, Di
Wei, Junjie
He, Zhe
Xiong, Lan-Tu
Zeng, Yan
Song, Gaopeng
Deng, Xin
Cui, Zi-Ning
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (31) : 17210 - 17218
[35] Mutations in the Pseudomonas aeruginosa Needle Protein Gene pscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System
Bowlin, Nicholas O.
Williams, John D.
Knoten, Claire A.
Torhan, Matthew C.
Tashjian, Tommy F.
Li, Bing
Aiello, Daniel
Mecsas, Joan
Hauser, Alan R.
Peet, Norton P.
Bowlin, Terry L.
Moir, Donald T.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (04) : 2211 - 2220
[36] Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells
Sandra Muschiol
Staffan Normark
Birgitta Henriques-Normark
Agathe Subtil
BMC Microbiology, 9
[37] Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells
Muschiol, Sandra
Normark, Staffan
Henriques-Normark, Birgitta
Subtil, Agathe
BMC MICROBIOLOGY, 2009, 9
[38] Xanthomonas type III secretion system based analysis of candidate effectors from Blumeria graminis f. sp hordei
Jayasena, A. S.
Meng, Y.
Bindschedler, L.
Spanu, P.
Wise, R.
Bogdanove, A.
PHYTOPATHOLOGY, 2010, 100 (06) : S56 - S56
[39] Type III Secretion System of Bradyrhizobium sp. SUTN9-2 Obstructs Symbiosis with Lotus spp.
Hashimoto, Shun
Goto, Kohki
Pyromyou, Pongdet
Songwattana, Pongpan
Greetatorn, Teerana
Tittabutr, Panlada
Boonkerd, Nantakorn
Teaumroong, Neung
Uchiumi, Toshiki
MICROBES AND ENVIRONMENTS, 2020, 35 (03) : 1 - 5
[40] Identification of Benzyloxy Carbonimidoyl Dicyanide Derivatives as Novel Type III Secretion System Inhibitors via High-Throughput Screening
Ma, Yi-Nan
Chen, Liang
Si, Nai-Guo
Jiang, Wen-Jun
Zhou, Zhi-Gang
Liu, Jun-Li
Zhang, Li-Qun
FRONTIERS IN PLANT SCIENCE, 2019, 10

← 1 2 3 4 5 →