Guadinomines, Type III secretion system inhibitors, produced by streptomyces sp K01-0509

被引：41

作者：

Iwatsuki, Masato ^{[2
]}

Uchida, Ryuji ^{[2
]}

Yoshijima, Hitomi ^{[1
]}

Ui, Hideaki ^{[1
]}

Shiomi, Kazuro ^{[1
]}

Kim, Yong-Pil ^{[2
]}

Hirose, Tomoyasu ^{[2
]}

Sunazuka, Toshiaki ^{[1
]}

Abe, Akio ^{[1
]}

Tomoda, Hiroshi ^{[1
]}

Omura, Satoshi ^{[1
,2
]}

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 04期

关键词：

guadinomines; Type III secretion system; Streptomyces sp K01-0509; EPEC;

D O I：

10.1038/ja.2008.33

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of guadinomines, new inhibitors of a bacterial Type III secretion system produced by Streptomyces sp. KOI-0509, were elucidated by spectroscopic studies including various NMR experiments. Guadinomines A, B, C-1, C-2 and D consist of a carbamoylated cyclic guanidinyl moiety, an alkyl chain moiety and an L-Ala-L-Val moiety in common, while guadinomic acid is a smaller molecule consisting of a carbamoylated cyclic guanidinyl moiety and a hydroxyl hexanoate moiety.

引用

页码：230 / 236

页数：7

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