共 50 条
- [41] Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1ACS MEDICINAL CHEMISTRY LETTERS, 2024, 15 (09): : 1606 - 1614Tellis, John C.Wei, BinQingSiu, MichaelAn, LeChan, Grace KayanChen, YongDu, XiangnanGazzard, LewisHu, BaihuaKiefer, JamesKakiuchi-Kiyota, SatokoLainchbury, MichaelLinehan, Jonathan L.Luo, XifengMalhotra, SushantMendonca, RohanPang, JodieRan, YinqingSethuraman, VijaySeward, EileenSneeringer, ChrisSu, DianWang, WeiruWu, PingMoffat, John G.Heffron, Timothy P.Choo, Edna F.Chan, Bryan K.
- [42] Anti-tumor effect of orally available small molecule PD-L1 inhibitors in a murine model of colon adenocarcinomaCANCER RESEARCH, 2020, 80 (16)Li, ShijieVilalta, MartaErtl, Linda S.Wang, YuZeng, YibinFan, PingchenLange, ChristopherMcMurtrie, DarrenYang, JuLui, RebeccaOng, RyanChhina, VickyKumamoto, AliceYau, SimonDang, TonEasterday, AshtonLiu, ShirleySingh, RajinderCharo, IsraelSchall, Thomas J.Zhang, Penglie
- [43] INCB090244, A POTENT SMALL MOLECULE THAT INHIBITS THE PD-L1/PD-1 AXIS AND FUNCTIONS SIMILARLY TO PD-L1 ANTIBODIESJOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A247 - A247Rios-Doria, JonathanVolgina, AllaGokhale, PrafullaLiu, HaoStevens, ChristinaZolotarjova, NinaDiMatteo, DarliseKapilashrami, KanishkBehshad, ElhamThekkat, PramodYang, GengjieHall, LeslieKanellopoulou, ChrysiRupar, MarkMaddage, ChristopherHorsey, AprilBurke, KristaYang, Yan-ouCovington, MaryanneWang, SteveLiu, PhillipWynn, RichardReardon, DavidKoblish, Holly
- [44] Novel small-molecule antagonists of the PD-1/PD-L1 axis that mediate cell surface PD-L1 dimerization and internalizationCANCER RESEARCH, 2019, 79 (13)Liu, Phillip C. C.Wynn, RichardWu, LiangxingVolgina, AllaZolotarjova, NinaLin, LupingThekkat, PramodMargulis, AlexKlabe, RonaldYao, WenqingXiao, KaijiongLi, JingweiHe, XinRupar, MarkChang, HongWaeltz, PaulLi, YanlongScherle, PeggyHuber, ReidHollis, Gregory
- [45] Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapyCELL COMMUNICATION AND SIGNALING, 2024, 22 (01)Jin, ShengzheWang, HongfeiLi, YangYang, JingwenLi, BeibeiShi, PeishangZhang, XiangruiZhou, XiaowenZhou, XiumanNiu, XiaoshuangWu, MenghanWu, YahongZhai, WenjieQi, YuanmingGao, YanfengZhao, Wenshan
- [46] Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapyCell Communication and Signaling, 22Shengzhe JinHongfei WangYang LiJingwen YangBeibei LiPeishang ShiXiangrui ZhangXiaowen ZhouXiuman ZhouXiaoshuang NiuMenghan WuYahong WuWenjie ZhaiYuanming QiYanfeng GaoWenshan Zhao
- [47] THE SMALL MOLECULE PD-L1 INHIBITOR CCX559 PREFERENTIALLY ACCUMULATES IN TUMORS, RESULTING IN DEPLETION OF CELL-SURFACE PD-L1 IN A MURINE PRECLINICAL MODELJOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A520 - A520Sullivan, KathleenErtl, LindaMiao, ZhenhuaFan, PingchenZeng, YibinDunlap, CarolynEbsworth, KarenGupta, SupritLi, Shijie ChrisDang, TonMiao, ShichangCharo, IsraelSchall, ThomasZhang, Penglie
- [48] Covalent small-molecule inhibitors of the PD-1/PD-L1 immune checkpointFEBS OPEN BIO, 2024, 14 : 329 - 330Maslanka, A.Kitel, R.Konopka, J.Skalniak, L.
- [49] In vitro assay for the development of small molecule inhibitors targeting PD-1/PD-L1TUMOR IMMUNOLOGY AND IMMUNOTHERAPY - MOLECULAR METHODS, 2019, 629 : 361 - 381Zhai, WenjieZhou, XiumanDu, JiangfengGao, Yanfeng
- [50] PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer TherapyMOLECULAR CANCER THERAPEUTICS, 2010, 9 (04) : 883 - 894Jani, Jitesh P.Arcari, JoelBernardo, VincentBhattacharya, Samit K.Briere, DavidCohen, Bruce D.Coleman, KevinChristensen, James G.Emerson, Erling O.Jakowski, AmyHook, KennethLos, GerritMoyer, James D.Pruimboom-Brees, IngridPustilnik, LeslieRossi, Ann MarieSteyn, Stefan J.Su, ChunyanTsaparikos, KonstantinosWishka, DonnYoon, KwansikJakubczak, John L.