Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy

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作者
Shengzhe Jin
Hongfei Wang
Yang Li
Jingwen Yang
Beibei Li
Peishang Shi
Xiangrui Zhang
Xiaowen Zhou
Xiuman Zhou
Xiaoshuang Niu
Menghan Wu
Yahong Wu
Wenjie Zhai
Yuanming Qi
Yanfeng Gao
Wenshan Zhao
机构
[1] Zhengzhou University,School of Life Sciences
[2] Xinxiang Medical University,Henan Key Laboratory of Immunology and Targeted Drugs, School of Medical Technology
[3] Shenzhen Campus of Sun Yat-Sen University,School of Pharmaceutical Sciences (Shenzhen)
[4] Zhengzhou University,International Joint Laboratory for Protein and Peptide Drugs of Henan Province
关键词
Tumor microenvironment; Immune checkpoint blockade; PD-1/PD-L1; CD47/SIRPα; Radiotherapy;
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