Base-Promoted Difunctionalization of Alkynes: One-Pot Synthesis of Polysubstituted Chromones

被引：0
|
作者：
Wang, Mengdan [1 ]
Cheng, Lu [2 ]
Ma, Junying [1 ]
Lu, Weiwei [1 ]
Wang, Junling [1 ]
机构：
[1] Henan Univ Sci & Technol Luoyang, Sch Chem Engn & Pharmaceut, Luoyang 471003, Henan, Peoples R China
[2] East China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 32期
关键词：
difunctionalization of alkynes; one-pot; transition-metal-free; C-C triple bond oxidation; synthesis; TRIPLE BOND-CLEAVAGE; CARBON SIGMA-BONDS; ANTI-MARKOVNIKOV HYDRATION; STEREOSELECTIVE DIFUNCTIONALIZATION; PRIVILEGED SCAFFOLD; OXIDATIVE CLEAVAGE; CARBOXYLIC-ACIDS; TERMINAL ALKYNES; TANDEM REACTION; DRUG DISCOVERY;
D O I：
10.1002/ejoc.202300456
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A transition-metal-free one-pot procedure for the difunctionalization of alkynes by C-C triple bond oxidation and transformation towards chromone derivatives has been developed. It involves cascade reactions for carbonylation of alkynes, base-promoted C-C & sigma;-bond cleavage, and intramolecular cyclization. This procedure provides an efficient protocol for the synthesis of polysubstituted chromones from readily available starting materials.
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页数：5
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