Base-Promoted One-Pot Tandem Reaction of 3-(1-Alkynyl)chromones under Microwave Irradiation to Functionalized Amino-Substituted Xanthones

被引：32
|
作者：
Liu, Yang [1 ]
Huang, Liping [1 ]
Xie, Fuchun [1 ]
Hu, Youhong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 18期
基金：
中国国家自然科学基金;
关键词：
ASSISTED ORGANIC-SYNTHESIS; TETRASUBSTITUTED FURANS; CASCADE REACTIONS; DOMINO REACTIONS; 2-(1-ALKYNYL)-2-ALKEN-1-ONES; CYCLIZATION; STRATEGIES; SEQUENCES; SCAFFOLD; SYSTEM;
D O I：
10.1021/jo1013614
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A base-promoted one-pot tandem reaction has been developed from 3-(1-alkynyl)chromones with various acetonitriles to afford functionalized amino-substituted xanthones 3 under microwave irradiation. This tandem process involves multiple reactions, such as Michael addition/cyclization/1,2-addition, without a transition metal catalyst. This method provides an efficient approach to build up natural product-like diversified amino-substituted xanthone scaffolds rapidly.
引用
收藏
页码：6304 / 6307
页数：4
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