Base-Promoted One-Pot Strategy for Expeditious Assembly of Highly Functionalized Benzocoumarin Derivatives

被引：0

作者：

Rakaee, Fataneh ^{[1
]}

Shiri, Morteza ^{[1
]}

Farajpour, Behnaz ^{[1
]}

Majedi, Serveh ^{[2
]}

Seraj, Mahsa ^{[1
]}

Moradkhani, Fatemeh ^{[3
,4
]}

Taheri, Salman ^{[5
]}

Sadeghi-Dolatabadi, Mohammad Reza ^{[1
]}

Majedi, Soma ^{[6
]}

机构：

[1] Alzahra Univ, Fac Chem, Dept Organ Chem, Tehran 1993893973, Iran

[2] Payame Noor Univ, Dept Chem, Tehran 1993893973, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran 1993893973, Iran

[4] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 1993893973, Iran

[5] Chem & Chem Engn Res Ctr Iran, Tehran 1993893973, Iran

[6] Tishk Int Univ, Pharm Dept, Erbil 44001, Kurdistan Reg, Iraq

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年

基金：

美国国家科学基金会;

关键词：

ANTI-TUMOR ANTIBIOTICS; GILVOCARCINS; CYCLIZATION; ACIDS;

D O I：

10.1021/acs.joc.4c01879

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile and atom-economic three-component reaction between 3-cyano-4-styrylcoumarins, 1,3-indandione, and aliphatic alcohols is described for synthesizing diversely multifunctionalized benzocoumarins. This strategy allows facile access to various benzocoumarins bearing an amine and a substituted benzoyl scaffold under simple heating conditions. Readily available precursors, operational simplicity, acceptable functional group tolerance, and excellent yields are some highlighted advantages of this transformation.

引用

页数：8

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