One pot synthesis of 2-substituted thiobenzoazoles containing α-sulfenylated aromatic ketones under transition metal-free conditions

被引：0

作者：

Cheng, Xi ^{[1
]}

Xu, Xiao-Hu ^{[2
]}

Dong, Zhi-Bing ^{[1
,3
,4
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang, Peoples R China

[3] Minist Educ, Wuhan Inst Technol, Key Lab Green Chem Proc, Wuhan, Peoples R China

[4] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 10期

关键词：

EFFICIENT SYNTHESIS; BOND-CLEAVAGE;

D O I：

10.1002/jhet.4721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 2-substituted thiobenzoazoles in pot manner was reported. Thus, tetramethylthiuram disulfide (TMTD) reacted with 2-aminothiophenol, 2-aminophenol, or 1,2-phenylenediamine to form 2-mercaptobenzo heterocycles through cyclization, and the subsequent C-S bonding with 2-bromoacetophenones gave the desired 2-substituted thiobenzoazoles containing & alpha;-sulfenylated aromatic ketones smoothly. The method features transition metal-free, simple operation, mild conditions, short reaction time, and good yields, showing potential synthetic value for the synthesis of a variety of biological or pharmaceutically active compounds.

引用

页码：1793 / 1798

页数：6

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