Transition Metal and Base-Free Electro-Oxidative Regioselective Trifluoromethylation of Imidazo[1,2-a]pyridines

被引：6
|
作者：
Halder, Atreyee [1 ]
Ghosh, Sayan [1 ]
De Sarkar, Suman [1 ]
机构：
[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, India
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 08期
关键词：
Electrosynthesis; Imidazopyridine; Radical; C-C-bond-formation; Trifluoromethylation; C-H TRIFLUOROMETHYLATION; FUNCTIONALIZATION; LIGHT; IMIDAZOHETEROCYCLES; PHARMACEUTICALS; HETEROCYCLES; FLUORINE; DESIGN; COPPER;
D O I：
10.1002/ajoc.202300294
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A green electrochemical C(sp(2))-H trifluoromethylation of imidazo[1,2-a]pyridines by engaging Langlois' reagent is reported. This oxidative regioselective CF3-functionalization strategy operates under open atmosphere, in an undivided cell and at ambient temperature. Regioselective C-CF3 bond formation was achieved exclusively by applying this mild protocol exhibiting broad functional group compatibility affording the desired product up to 79% isolated yield. Mechanistic studies indicated a radical pathway for this electrochemical redox transformation.
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页数：5
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