Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones

被引：6
|
作者：
Shi, Jianwei [1 ]
Wang, Zhichuan [2 ]
Teng, Xiaoxu [1 ]
Zhang, Bing [3 ]
Sun, Kai [2 ]
Wang, Xin [2 ]
机构：
[1] Yangtze Normal Univ, Sch Chem & Chem Engn, Chongqing 408100, Peoples R China
[2] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China
[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 05期
基金：
中国国家自然科学基金;
关键词：
electrochemistry; selenylation; radical; carbocation; N-heterocycles; EFFLUX PUMP INHIBITORS; PSEUDOMONAS-AERUGINOSA; ORGANOSELENIUM; CYCLIZATION; DERIVATIVES; ALKENES;
D O I：
10.3390/molecules28052206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.
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页数：17
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