Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones

被引：6

作者：

Shi, Jianwei ^{[1
]}

Wang, Zhichuan ^{[2
]}

Teng, Xiaoxu ^{[1
]}

Zhang, Bing ^{[3
]}

Sun, Kai ^{[2
]}

Wang, Xin ^{[2
]}

机构：

[1] Yangtze Normal Univ, Sch Chem & Chem Engn, Chongqing 408100, Peoples R China

[2] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China

[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 05期

基金：

中国国家自然科学基金;

关键词：

electrochemistry; selenylation; radical; carbocation; N-heterocycles; EFFLUX PUMP INHIBITORS; PSEUDOMONAS-AERUGINOSA; ORGANOSELENIUM; CYCLIZATION; DERIVATIVES; ALKENES;

D O I：

10.3390/molecules28052206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.

引用

页数：17

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