Lactones from Glomerella cingulata Cultivated in Rice: Structural Studies and Antimicrobial Evaluation

被引：0
|
作者：
Gomes, Nayara F. [1 ]
Junior, Manoel Leao L. [2 ]
Filho, Antonio Jose C. [1 ]
Santos, Lourivaldo S. [2 ]
Silva, Luis Claudio N. [3 ]
Rodrigues-Filho, Edson [4 ]
机构：
[1] Fed Inst Educ Sci & Technol Maranhao, Grad Program Chem, BR-65030005 Sao Luis, Maranhao, Brazil
[2] Fed Univ Para, Inst Exact & Nat Sci, BR-65075110 Belem, Para, Brazil
[3] Univ Ceuma, Grad Program, BR-65075120 Sao Luis, Maranhao, Brazil
[4] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil
来源：
RECORDS OF NATURAL PRODUCTS | 2023年 / 17卷 / 01期
关键词：
Endophytic fungus; Glomerella cingulata; antimicrobial activity; SECONDARY METABOLITES; COLLETOTRICHUM;
D O I：
10.25135/rnp.340.2202.2352
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly H-1 and C-13 NMR and HRMS. These analyzes allowed the identification of pestalotin-1 (1) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (2) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (3). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereomer 3 and pestalotin-1 were inactive.
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页码：195 / 200
页数：6
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