Targeting the Cell Cycle Checkpoints CHK1 and CHK2 is a Novel Therapeutic Approach for Pediatric Neuroblastoma

被引:0
|
作者
Morrison, Ben [1 ]
Chilamakuri, Rameswari [1 ]
Agarwal, Saurabh
机构
[1] St Johns Univ, Jamaica, NY 11439 USA
关键词
D O I
10.1124/jpet.122.230730
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
49
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
    Russell, Mike R.
    Levin, Kirill
    Rader, JulieAnn
    Belcastro, Lili
    Li, Yimei
    Martinez, Daniel
    Pawel, Bruce
    Shumway, Stuart D.
    Maris, John M.
    Cole, Kristina A.
    CANCER RESEARCH, 2013, 73 (02) : 776 - 784
  • [32] The 1.7 Å crystal structure of human cell cycle checkpoint kinase Chk1:: Implications for Chk1 regulation
    Chen, P
    Luo, C
    Deng, YL
    Ryan, K
    Register, J
    Margosiak, S
    Tempczyk-Russell, A
    Nguyen, B
    Myers, P
    Lundgren, K
    Kan, CC
    O'Connor, PM
    CELL, 2000, 100 (06) : 681 - 692
  • [33] ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells
    Ronco, Cyril
    Martin, Anthony R.
    Demange, Luc
    Benhida, Rachid
    MEDCHEMCOMM, 2017, 8 (02) : 295 - 319
  • [34] CHK1和CHK2在食管癌组织中的表达
    王玉祥
    祝淑钗
    王鑫
    封巍
    李娟
    沈文斌
    肿瘤防治研究 , 2006, (03) : 171 - 174
  • [35] Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death
    van Harten, Anne M.
    Buijze, Marijke
    van der Mast, Richard
    Rooimans, Martin A.
    Martens-de Kemp, Sanne R.
    Bachas, Costa
    Brink, Arjen
    Stigter-van Walsum, Marijke
    Wolthuis, Rob M. F.
    Brakenhoff, Ruud H.
    ONCOGENESIS, 2019, 8 (7)
  • [36] Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
    Myoung-Ae Kim
    Hyun-Ju Kim
    Alexandra L Brown
    Min-Young Lee
    Yoe-Sik Bae
    Joo-In Park
    Jong-Young Kwak
    Jay H Chung
    Jeanho Yun
    Experimental & Molecular Medicine, 2007, 39 : 205 - 212
  • [37] Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins
    Huang, Min
    Miao, Ze-Hong
    Zhu, Hong
    Cai, Yu-Jun
    Lu, Wei
    Ding, Jian
    MOLECULAR CANCER THERAPEUTICS, 2008, 7 (06) : 1440 - 1449
  • [38] Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death
    Anne M. van Harten
    Marijke Buijze
    Richard van der Mast
    Martin A. Rooimans
    Sanne R. Martens-de Kemp
    Costa Bachas
    Arjen Brink
    Marijke Stigter-van Walsum
    Rob M. F. Wolthuis
    Ruud H. Brakenhoff
    Oncogenesis, 8
  • [39] MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
    Wang, Wen-Jun
    Wu, Si-Pei
    Liu, Jia-Bin
    Shi, Yong-Sheng
    Huang, Xue
    Zhang, Qian-Bing
    Yao, Kai-Tai
    CANCER RESEARCH, 2013, 73 (03) : 1219 - 1231
  • [40] Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
    Kim, Myoung-Ae
    Kim, Hyun-Ju
    Brown, Alexandra L.
    Lee, Min-Young
    Bae, Yoe-Sik
    Park, Joo-In
    Kwak, Jong-Young
    Chung, Jay H.
    Yun, Jeanho
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2007, 39 (02): : 205 - 212