Synthesis of HC-Toxin via Matteson Homologation and C-H Functionalization

被引：2
|
作者：
Kohr, Michael [1 ]
Kazmaier, Uli [1 ]
机构：
[1] Saarland Univ, Organ Chem 1, D-66123 Saarbrucken, Germany
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期
关键词：
HOST-SPECIFIC TOXIN; BORONIC ESTERS; STEREOSELECTIVE-SYNTHESIS; STEREOSPECIFIC SYNTHESIS; ACID; CHLAMYDOCIN; CONVENIENT; TOOLBOX; EPOXIDE; BONDS;
D O I：
10.1021/acs.joc.3c00914
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthetic routetoward host-specific HC-toxin wasdeveloped.The HC-toxin belongs to a group of cyclic, tetrapeptide histone deacetylaseinhibitors containing the unusual amino acid Aeo. Key steps in thesynthesis of this building block include the Matteson homologationto generate the stereogenic centers in the side chain and a C-Hfunctionalization to connect the side chain to a protected alanine.
引用
收藏
页码：10869 / 10880
页数：12
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