Induced pluripotent stem cell technology in bone biology

被引：5
|
作者：
Kidwai, Fahad K. [1 ,3 ]
Canalis, Ernesto [2 ]
Robey, Pamela G. [1 ]
机构：
[1] Natl Inst Dent & Craniofacial Res, Skeletal Biol Sect, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
[2] UConn Hlth, UConn Musculoskeletal Inst, Ctr Skeletal Res Orthoped Surg & Med, Farmington, CT 06030 USA
[3] Natl Inst Child Hlth Dev, Sect Mol & Therapies Craniofacial & Dent Disorders, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
来源：
BONE | 2023年 / 172卷
基金：
美国国家卫生研究院;
关键词：
Pluripotent stem cells; Induced pluripotent stem cells R; Reprogramming; Osteogenic differentiation; Models of disease; NEURAL CREST DEVELOPMENT; HAJDU-CHENEY-SYNDROME; IN-VITRO; ALAGILLE-SYNDROME; MOUSE MODEL; DIRECTED DIFFERENTIATION; NOTCH; EXPRESSION; MESODERM; GENE;
D O I：
10.1016/j.bone.2023.116760
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Technologies on the development and differentiation of human induced pluripotent stem cells (hiPSCs) are rapidly improving, and have been applied to create cell types relevant to the bone field. Differentiation protocols to form bona fide bone-forming cells from iPSCs are available, and can be used to probe details of differentiation and function in depth. When applied to iPSCs bearing disease-causing mutations, the pathogenetic mechanisms of diseases of the skeleton can be elucidated, along with the development of novel therapeutics. These cells can also be used for development of cell therapies for cell and tissue replacement.
引用
收藏
页数：13
相关论文
共 50 条
  • [41] Human Induced Pluripotent Stem Cell-Derived Macrophages for Unraveling Human Macrophage Biology
    Zhang, Hanrui
    Reilly, Muredach P.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2017, 37 (11) : 2000 - 2006
  • [42] Interactions between induced pluripotent stem cells and stem cell niche augment osteogenesis and bone regeneration
    Ding Z.
    Pan X.
    Wang X.
    Xie H.
    Ye Q.
    Smart Materials in Medicine, 2021, 2 : 196 - 208
  • [43] Induced Pluripotent Stem Cell Consensus Genes: Implication for the Risk of Tumorigenesis and Cancers in Induced Pluripotent Stem Cell Therapy
    Zhang, Gaochuan
    Shang, Bingxue
    Yang, Ping
    Cao, Zhifei
    Pan, Yanyan
    Zhou, Quansheng
    STEM CELLS AND DEVELOPMENT, 2012, 21 (06) : 955 - 964
  • [44] The Next Frontier for Pluripotent Stem Cell Research in Reproductive Biology
    Clark, Amander
    BIOLOGY OF REPRODUCTION, 2011, 85
  • [45] Utilizing FUCCI reporters to understand pluripotent stem cell biology
    Singh, Amar M.
    Trost, Robert
    Boward, Benjamin
    Dalton, Stephen
    METHODS, 2016, 101 : 4 - 10
  • [46] The Next Frontier for Pluripotent Stem Cell Research in Reproductive Biology
    Clark, Amander
    BIOLOGY OF REPRODUCTION, 2011, 85
  • [47] Generation of Human Induced Pluripotent Stem Cell-Derived Bone Marrow Organoids
    Frenz, Stephanie
    Goek, Isabel
    Buser, Maximilian
    Salewskij, Kirill
    Fairley, Savannah
    Conca, Raffaele
    Drexler, Nicole
    Jonsson, Gustav
    Thomas, Moritz
    Mizoguchi, Yoko
    Rudelius, Martina
    Heuser, Thomas
    Marr, Carsten
    Penninger, Josef M.
    Klein, Christoph
    BLOOD, 2022, 140 : 1682 - 1683
  • [48] Recapitulating Long-QT Syndrome Using Induced Pluripotent Stem Cell Technology
    Dirschinger, Ralf J.
    Goedel, Alexander
    Moretti, Alessandra
    Laugwitz, Karl-Ludwig
    Sinnecker, Daniel
    PEDIATRIC CARDIOLOGY, 2012, 33 (06) : 950 - 958
  • [49] Evaluation of Redox Dysregulation in the Pathology of Schizophrenia Using Induced Pluripotent Stem Cell Technology
    Giangreco, Basilio
    Steullet, Pascal
    Cabungcal, Jan-Harry
    Bartesaghi, Luca
    Toni, Nicolas
    Chrast, Roman
    Do, Kim Q.
    BIOLOGICAL PSYCHIATRY, 2014, 75 (09) : 186S - 186S
  • [50] Recapitulating Long-QT Syndrome Using Induced Pluripotent Stem Cell Technology
    Ralf J. Dirschinger
    Alexander Goedel
    Alessandra Moretti
    Karl-Ludwig Laugwitz
    Daniel Sinnecker
    Pediatric Cardiology, 2012, 33 : 950 - 958
12345