Induced pluripotent stem cell technology in bone biology

被引：5
|
作者：
Kidwai, Fahad K. [1 ,3 ]
Canalis, Ernesto [2 ]
Robey, Pamela G. [1 ]
机构：
[1] Natl Inst Dent & Craniofacial Res, Skeletal Biol Sect, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
[2] UConn Hlth, UConn Musculoskeletal Inst, Ctr Skeletal Res Orthoped Surg & Med, Farmington, CT 06030 USA
[3] Natl Inst Child Hlth Dev, Sect Mol & Therapies Craniofacial & Dent Disorders, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
来源：
BONE | 2023年 / 172卷
基金：
美国国家卫生研究院;
关键词：
Pluripotent stem cells; Induced pluripotent stem cells R; Reprogramming; Osteogenic differentiation; Models of disease; NEURAL CREST DEVELOPMENT; HAJDU-CHENEY-SYNDROME; IN-VITRO; ALAGILLE-SYNDROME; MOUSE MODEL; DIRECTED DIFFERENTIATION; NOTCH; EXPRESSION; MESODERM; GENE;
D O I：
10.1016/j.bone.2023.116760
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Technologies on the development and differentiation of human induced pluripotent stem cells (hiPSCs) are rapidly improving, and have been applied to create cell types relevant to the bone field. Differentiation protocols to form bona fide bone-forming cells from iPSCs are available, and can be used to probe details of differentiation and function in depth. When applied to iPSCs bearing disease-causing mutations, the pathogenetic mechanisms of diseases of the skeleton can be elucidated, along with the development of novel therapeutics. These cells can also be used for development of cell therapies for cell and tissue replacement.
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收藏
页数：13
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