Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer

被引：6

作者：

Giatromanolaki, Alexandra ^{[1
]}

Chatzipantelis, Paschalis ^{[1
]}

Contrafouris, Constantinos A. ^{[2
]}

Koukourakis, Michael, I ^{[3
]}

机构：

[1] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Pathol, Alexandroupolis, Greece

[2] Onassis Cardiac Surg Ctr, Cardiac Surg Dept 1, Athens, Greece

[3] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Radiotherapy Oncol, Alexandroupolis, Greece

来源：

CANCER INVESTIGATION | 2023年 / 41卷 / 01期

关键词：

Non-small-cell lung cancer; tertiary lymphoid structures; tumor-infiltrating lymphocytes; prognosis; TUMOR-INFILTRATING LYMPHOCYTES; B-CELLS; TISSUE; ACIDITY; MICE;

D O I：

10.1080/07357907.2022.2136684

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We assessed the presence of 'tertiary lymphoid structures' (TLS) in a series of surgically treated non-small cell lung carcinomas (NSCLC). The TLS-density in the tumor periphery (pTLS) ranged from 0 to 1.8 (median 0.45), while in inner tumor areas (iTLS) ranged from 0 to 1.0 (median 0); (p < 0.0001). High pTLS-density was linked with early stage of the disease. Glycolysis-related enzyme expression (MCT1, Hexokinase 2) was linked with high pTLS-density (p < 0.05). High pTLS and iTLS densities were linked with better postoperative prognosis (p = 0.02 and p = 0.01, respectively). Assessment of TLS is a useful prognostic marker in NSCLC.

引用

页码：48 / 57

页数：10

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