Prognostic Immune Markers in Non-Small Cell Lung Cancer

被引：142

作者：

Suzuki, Kei ^{[1
]}

Kachala, Stefan S. ^{[1
]}

Kadota, Kyuichi ^{[1
,5
]}

Shen, Ronglai ^{[2
]}

Mo, Qianxing ^{[2
]}

Beer, David G. ^{[6
]}

Rusch, Valerie W. ^{[1
]}

Travis, William D. ^{[3
]}

Adusumilli, Prasad S. ^{[1
,4
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Div Thorac Surg, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10065 USA

[5] Kagawa Univ, Dept Pathol, Kagawa, Japan

[6] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

来源：

CLINICAL CANCER RESEARCH | 2011年 / 17卷 / 16期

关键词：

CD8(+) T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; GENE-EXPRESSION SIGNATURE; FAVORABLE PROGNOSIS; SURVIVAL PREDICTION; PATIENT SURVIVAL; CIGARETTE-SMOKE; DENDRITIC CELLS; ADENOCARCINOMA; MACROPHAGES;

D O I：

10.1158/1078-0432.CCR-10-2805

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated immune responses have polarized effects in regulating tumor growth. Although a clear association has been shown between the tumor immune response and clinical outcome in colorectal and ovarian cancers, the role of immune markers for stratifying prognosis in non-small cell lung cancer (NSCLC) is less defined. Herein, we review the prognostic significance of published immune markers in the tumor microenvironment and peripheral blood of NSCLC patients. To identify prognostic immune genes, we reviewed all published gene-profiling studies in NSCLC and delineated the significance of immune genes by doing subanalysis on the microarray database of the NIH Director's Challenge study. This first comprehensive review of prognostic immune markers provides a foundation for further investigating immune responses in NSCLC. Clin Cancer Res; 17(16); 5247-56. (C)2011 AACR.

引用

页码：5247 / 5256

页数：10

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