Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer

被引：6
|
作者：
Giatromanolaki, Alexandra [1 ]
Chatzipantelis, Paschalis [1 ]
Contrafouris, Constantinos A. [2 ]
Koukourakis, Michael, I [3 ]
机构：
[1] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Pathol, Alexandroupolis, Greece
[2] Onassis Cardiac Surg Ctr, Cardiac Surg Dept 1, Athens, Greece
[3] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Radiotherapy Oncol, Alexandroupolis, Greece
来源：
CANCER INVESTIGATION | 2023年 / 41卷 / 01期
关键词：
Non-small-cell lung cancer; tertiary lymphoid structures; tumor-infiltrating lymphocytes; prognosis; TUMOR-INFILTRATING LYMPHOCYTES; B-CELLS; TISSUE; ACIDITY; MICE;
D O I：
10.1080/07357907.2022.2136684
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We assessed the presence of 'tertiary lymphoid structures' (TLS) in a series of surgically treated non-small cell lung carcinomas (NSCLC). The TLS-density in the tumor periphery (pTLS) ranged from 0 to 1.8 (median 0.45), while in inner tumor areas (iTLS) ranged from 0 to 1.0 (median 0); (p < 0.0001). High pTLS-density was linked with early stage of the disease. Glycolysis-related enzyme expression (MCT1, Hexokinase 2) was linked with high pTLS-density (p < 0.05). High pTLS and iTLS densities were linked with better postoperative prognosis (p = 0.02 and p = 0.01, respectively). Assessment of TLS is a useful prognostic marker in NSCLC.
引用
收藏
页码：48 / 57
页数：10
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