Human colonic catabolism of dietary flavan-3-ol bioactives

被引：21

作者：

Di Pede, Giuseppe ^{[1
]}

Mena, Pedro ^{[1
,2
]}

Bresciani, Letizia ^{[1
]}

Almutairi, Tahani M. ^{[3
]}

Del Rio, Daniele ^{[1
,2
]}

Clifford, Michael N. ^{[4
,5
]}

Crozier, Alan ^{[3
,6
]}

机构：

[1] Univ Parma, Dept Food & Drug, Human Nutr Unit, I-43125 Parma, Italy

[2] Univ Parma, Microbiome Res Hub, I-43124 Parma, Italy

[3] King Saud Univ, Dept Chem, Riyadh 11363, Saudi Arabia

[4] Univ Surrey, Fac Hlth & Med Sci, Sch Biosci & Med, Guildford GU27XH, Surrey, England

[5] Monash Univ, Fac Med Nursing & Hlth Sci, Sch Clin Sci Monash Hlth, Dept Nutr Dietet & Food, Notting Hill, Vic 3168, Australia

[6] Univ Glasgow, Sch Med Dent & Nursing, Glasgow G128QQ, Scotland

来源：

MOLECULAR ASPECTS OF MEDICINE | 2023年 / 89卷

关键词：

Flavan-3-ols; Colonic catabolic and phase II metabolism; 2-14C](-)-Epicatechin; Procyanidins; Theaflavins; GREEN TEA FLAVAN-3-OLS; URINARY-EXCRETION; RED WINE; B2 EPICATECHIN-(4-BETA-8)-EPICATECHIN; ANTIADHESIVE ACTIVITY; PHENOLIC METABOLITES; PROCYANIDIN B2; HIPPURIC-ACID; A-TYPE; ABSORPTION;

D O I：

10.1016/j.mam.2022.101107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.

引用

页数：10

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