Cobalt-Catalyzed Asymmetric Hydrosilylation of ?-Oxygenated Ketones

被引：6

作者：

Wen, Huiting ^{[1
]}

Chen, Yifei ^{[1
]}

Shi, Lanxuan ^{[1
]}

Chen, Jianhui ^{[1
]}

Luo, Yanshu ^{[1
]}

Xia, Yuanzhi ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 13期

关键词：

ALPHA-HYDROXY KETONES; ENANTIOSELECTIVE HYDROSILYLATION; TRANSFER HYDROGENATION; KINETIC RESOLUTION; 1,2-AMINO ALCOHOLS; TERMINAL EPOXIDES; METAL; IRON; ALKENES; ARYL;

D O I：

10.1021/acs.orglett.3c00162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric hydrosilylation of alpha-oxygenated ketones was developed under the catalysis of Co(OAc)2 in combination with a chiral phosphine-amido-oxazoline (PAO) ligand, providing a mild, efficient, and enantioselective access to a variety of synthetically useful 1,2-diol derivatives. This protocol can be carried out at the gram scale with a catalyst loading of 1 mol %, and its synthetic utility was demonstrated by efficient conversion of the optically enriched products into chiral alpha-hydroxy acid, 1,3dioxolan-2-one, ethylene oxide, and 1,2,3-1H-triazole.

引用

页码：2184 / 2189

页数：6

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