Does granulocyte transfusion help pediatric cancer patients with sepsis?

被引:1
|
作者
Keerthivasagam, Swaminathan [1 ]
Srinivasan, Shyam [1 ]
Navkudkar, Anisha [2 ]
Chichra, Akanksha [1 ]
Moulik, Nirmalya Roy [1 ]
Dhamne, Chetan [1 ]
Narula, Gaurav [1 ]
Desai, Priti [2 ]
Chinnaswamy, Girish [1 ]
Banavali, Shripad [1 ]
机构
[1] Homi Bhabha Natl Inst, Tata Mem Ctr, Div Pediat oncol, Mumbai, Maharashtra, India
[2] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Immunohematol & Blood Transfus, Mumbai, Maharashtra, India
关键词
febrile neutropenia; granulocyte transfusion; pediatric cancer; sepsis; NEUTROPENIC PATIENTS; INFECTIONS; CHILDREN; PREVALENCE; EFFICACY;
D O I
10.1002/pbc.30547
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Sepsis-related mortality continues to be a major concern while treating pediatric cancer patients, more so with the rise in the incidence of multidrug-resistant organisms (MDRO). In this retrospective study conducted between January 2021 and December 2022 at a tertiary cancer center in India, granulocyte transfusion was offered in addition to standard antimicrobial therapy to 64 children with hematolymphoid malignancy who developed 75 episodes of severe sepsis following intensive chemotherapy. Forty-four (83%) of 53 blood culture proven sepsis was caused by MDROs. Thirty-seven (70%) patients with blood culture proven sepsis cleared the organism after granulocyte transfusion. Thirty-day mortality was 25% for the entire study cohort and 32% for patients with MDRO sepsis.
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页数:4
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