Does granulocyte transfusion help pediatric cancer patients with sepsis?

被引：1

作者：

Keerthivasagam, Swaminathan ^{[1
]}

Srinivasan, Shyam ^{[1
]}

Navkudkar, Anisha ^{[2
]}

Chichra, Akanksha ^{[1
]}

Moulik, Nirmalya Roy ^{[1
]}

Dhamne, Chetan ^{[1
]}

Narula, Gaurav ^{[1
]}

Desai, Priti ^{[2
]}

Chinnaswamy, Girish ^{[1
]}

Banavali, Shripad ^{[1
]}

机构：

[1] Homi Bhabha Natl Inst, Tata Mem Ctr, Div Pediat oncol, Mumbai, Maharashtra, India

[2] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Immunohematol & Blood Transfus, Mumbai, Maharashtra, India

来源：

PEDIATRIC BLOOD & CANCER | 2023年 / 70卷 / 09期

关键词：

febrile neutropenia; granulocyte transfusion; pediatric cancer; sepsis; NEUTROPENIC PATIENTS; INFECTIONS; CHILDREN; PREVALENCE; EFFICACY;

D O I：

10.1002/pbc.30547

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sepsis-related mortality continues to be a major concern while treating pediatric cancer patients, more so with the rise in the incidence of multidrug-resistant organisms (MDRO). In this retrospective study conducted between January 2021 and December 2022 at a tertiary cancer center in India, granulocyte transfusion was offered in addition to standard antimicrobial therapy to 64 children with hematolymphoid malignancy who developed 75 episodes of severe sepsis following intensive chemotherapy. Forty-four (83%) of 53 blood culture proven sepsis was caused by MDROs. Thirty-seven (70%) patients with blood culture proven sepsis cleared the organism after granulocyte transfusion. Thirty-day mortality was 25% for the entire study cohort and 32% for patients with MDRO sepsis.

引用

页数：4

共 50 条

[21] ASSESSING THE OUTCOMES OF PATIENTS FOLLOWING GRANULOCYTE TRANSFUSION
Rodger, D.
Varsou, O.
Soutar, R.
HAEMATOLOGICA, 2016, 101 : 649 - 649
[22] IMMUNOLOGICAL FOLLOW-UP OF INFANTS TREATED WITH GRANULOCYTE TRANSFUSION FOR NEONATAL SEPSIS
STEGAGNO, M
PASCONE, R
COLARIZI, P
LAURENTI, F
ISACCHI, G
BUCCI, G
DELUCA, EC
PEDIATRICS, 1985, 76 (04) : 508 - 511
[23] Does the "retrospectoscope'' help define best practices in transfusion?
Hammon, John W.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2015, 150 (01): : 214 - 215
[24] Blood transfusion does not affect survival of gastric cancer patients
Cui, Jingli
Deng, Jingyu
Ding, Xuewei
Zhang, Li
Zhang, Rupeng
Wu, Weipeng
Hao, Xishan
Liang, Han
JOURNAL OF SURGICAL RESEARCH, 2016, 200 (01) : 98 - 104
[25] EVALUATION OF IMMATURE GRANULOCYTE COUNTS IN PATIENTS WITH SEPSIS
Moraes, Daniela
Sgnaolin, Vanessa
Pagnussatti, Vany
Perrenoud, Myriam
Munhoz, Terezinha
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2012, 34 : 123 - 123
[26] Education may help reduce Yersinia sepsis from blood transfusion
Morris, A
MacCulloch, D
NEW ZEALAND MEDICAL JOURNAL, 1996, 109 (1014) : 19 - 19
[27] Successful treatment with granulocyte transfusion and early neutrophil engraftment in allogeneic transplant patients with febril neutropenia; do granulocyte transfusions help and accelerate neutrophil engraftment?
Unal, A.
Kaynar, L.
Keni, N.
Birekul, A.
Yildizhan, E.
Sivgin, S.
Eser, B.
Cetin, M.
BONE MARROW TRANSPLANTATION, 2017, 52 : S162 - S163
[28] An analysis of incidence and mortality of severe sepsis in pediatric cancer patients
Williams, MD
Cooper, LM
Qualy, R
Linde-Zwirble, W
CRITICAL CARE MEDICINE, 2003, 31 (12) : A17 - A17
[29] Mortality associated with restrictive threshold for red blood cell transfusion in pediatric patients with sepsis reply
Karam, Oliver
Tucci, Marisa
Ducruet, Thierry
Hume, Heather Ann
Lacroix, Jacques
Gauvin, France
PEDIATRIC CRITICAL CARE MEDICINE, 2012, 13 (04) : 495 - 495
[30] Transfusion in pediatric sepsis: Less may not be more, but it is at least as good
Parker, Margaret M.
PEDIATRIC CRITICAL CARE MEDICINE, 2011, 12 (05) : 592 - 593

← 1 2 3 4 5 →