Lactate, histone lactylation and cancer hallmarks

被引：69
|
作者：
Lv, Xinyu [1 ]
Lv, Yingying [2 ]
Dai, Xiaofeng [1 ,3 ]
机构：
[1] Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Peoples R China
[2] Shanghai Pudong New Area Peoples Hosp, Dept Clin Lab, Shanghai 201299, Peoples R China
[3] Xi An Jiao Tong Univ, Natl Local Joint Engn Res Ctr Precis Surg & Regene, Shaanxi Prov Ctr Regenerat Med & Surg Engn, Affiliated Hosp 1, Xian 710061, Peoples R China
来源：
EXPERT REVIEWS IN MOLECULAR MEDICINE | 2023年 / 25卷
基金：
中国国家自然科学基金;
关键词：
Cancer; epigenesis; hallmark; histone lactylation; lactate; therapeutic translation; DEHYDROGENASE; 5; EXPRESSION; LACTIC-ACID; TUMOR; CELLS; METABOLISM; RESISTANCE; GLYCOLYSIS; PH; INHIBITION; HYPOXIA;
D O I：
10.1017/erm.2022.42
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.
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页数：8
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