Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?

被引：1
|
作者：
Gong, Hang [1 ]
Xu, Hui-Mei [1 ]
Ma, Yao-Hui [1 ]
Zhang, De-Kui [1 ]
机构：
[1] Lanzhou Univ, Dept Gastroenterol, Hosp 2, Lanzhou, Gansu, Peoples R China
来源：
PHARMACOLOGICAL RESEARCH | 2023年 / 194卷
关键词：
Histone lactylation; Lactate; Glycolysis; Liver cancer; Tumorigenicity;
D O I：
10.1016/j.phrs.2023.106869
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
    Pan, Lianhong
    Feng, Fan
    Wu, Jiaqin
    Fan, Shibing
    Han, Juanjuan
    Wang, Shunxi
    Yang, Li
    Liu, Wanqian
    Wang, Chunli
    Xu, Kang
    PHARMACOLOGICAL RESEARCH, 2022, 181
  • [2] Reply to the letter titled: Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: Is it attributed to histone lactylation?
    Wang, Chunli
    Feng, Fan
    Pan, Lianhong
    Xu, Kang
    PHARMACOLOGICAL RESEARCH, 2023, 194
  • [3] Lactate, histone lactylation and cancer hallmarks
    Lv, Xinyu
    Lv, Yingying
    Dai, Xiaofeng
    EXPERT REVIEWS IN MOLECULAR MEDICINE, 2023, 25
  • [4] Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages
    Hu, Shian
    Yang, Zehua
    Li, Ling
    Yan, Qinwen
    Hu, Yutong
    Zhou, Feng
    Tan, Yang
    Pei, Gang
    MOLECULES, 2024, 29 (01):
  • [5] Lactate promotes the epithelial-mesenchymal transition of liver cancer cells via TWIST1 lactylation
    Wang, Huimin
    Wu, Xin
    Yu, Shan
    Zhang, Junwang
    Wen, Jing
    Wang, Yuan
    Liu, Qingtong
    Li, Xiaohui
    Yao, Jia
    Yuan, Lili
    EXPERIMENTAL CELL RESEARCH, 2025, 447 (01)
  • [6] Endothelial Cell-Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis
    Wu, Jinhui
    Hu, Miao
    Jiang, Heng
    Ma, Jun
    Xie, Chong
    Zhang, Zheng
    Zhou, Xin
    Zhao, Jianquan
    Tao, Zhengbo
    Meng, Yichen
    Cai, Zhuyun
    Song, Tengfei
    Zhang, Chenglin
    Gao, Rui
    Cai, Chang
    Song, Hongyuan
    Gao, Yang
    Lin, Tao
    Wang, Ce
    Zhou, Xuhui
    ADVANCED SCIENCE, 2023, 10 (31)
  • [7] Curcumin targets stem-like liver cancer cells by NF-kB mediated inhibition of histone deacetylases
    Marquardt, Jens U.
    Gomez-Quiroz, Luis E.
    Camacho, Lucrecia O. Arreguin
    Pinna, Frederico
    Lee, Yun-Han
    Kitade, Mitsuteru
    Andersen, Jesper B.
    Breuhahn, Kai
    Galle, Peter R.
    Factor, Valentina M.
    Thorgeirsson, Snorri S.
    HEPATOLOGY, 2014, 60 : 639A - 639A
  • [8] The histone deacetylase SIRT2 regulates the cell proliferation and tumorigenicity of glioblastoma cancer stem cells
    Funato, Kosuke
    Nasu-Nishimura, Yukiko
    Echizen, Kanae
    Todo, Tomoki
    Ino, Yasushi
    Saito, Nobuhito
    Koyama-Nasu, Ryo
    Oda, Takeaki
    Akiyama, Tetsu
    CANCER RESEARCH, 2011, 71
  • [9] Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis
    Sun, Qi
    Lesperance, Jacqueline
    Wettersten, Hiromi
    Luterstein, Elaine
    DeRose, Yoko S.
    Welm, Alana
    Cheresh, David A.
    Desgrosellier, Jay S.
    JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (01): : 531 - 544
  • [10] An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells
    Xavier, Pedro L. P.
    Cordeiro, Yonara G.
    Alexandre, Pamela A.
    Pires, Pedro R. L.
    Saranholi, Bruno H.
    Silva, Edson R.
    Mueller, Susanne
    Fukumasu, Heidge
    SCIENTIFIC REPORTS, 2019, 9 (1)
12345