Facile access to ?-hydroxyl ketones via a cobalt-catalyzed ring-opening/hydroxylation cascade of cyclopropanols

被引：5
|
作者：
Zhai, Shengxian [1 ]
Qiu, Shuxian [2 ]
Yang, Shuangtao [1 ]
Gao, Xingyuan [2 ]
Feng, Xinyu [1 ]
Yun, Chenzhe [1 ]
Han, Ning [1 ]
Niu, Yongsheng [1 ]
Wang, Jing [1 ]
Zhai, Hongbin [3 ,4 ,5 ,6 ]
机构：
[1] Anyang Inst Technol, Coll Chem & Environm Engn, Anyang 455000, Peoples R China
[2] Guangdong Univ Educ, Engn Technol Dev Ctr Adv Mat & Energy Saving Emiss, Guangzhou 510303, Peoples R China
[3] Peking Univ, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
[4] Peking Univ, Key Lab Chem Genom, Shenzhen Engn Lab Nano Drug Slow Release, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
[5] Shenzhen Bay Lab, Shenzhen 518055, Peoples R China
[6] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2023年 / 34卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Cobalt catalysis; Ring-opening; Cyclopropanol; -Hydroxy ketone; Cascade reaction; C BOND-CLEAVAGE; EFFICIENT SYNTHESIS; H ACTIVATION; VINYL AZIDES; BETA; STRATEGY; FUNCTIONALIZATION; CHEMISTRY; TRIFLUOROMETHYLATION; FLUORINATION;
D O I：
10.1016/j.cclet.2022.06.080
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A cobalt-catalyzed ring-opening/hydroxylation cascade of highly strained cyclopropanols has been developed for the first time. The reaction was conducted under open-air atmosphere to afford a broad series of structurally diverse /3-hydroxy ketones in moderate to good yields with high regioselectivity. The protocol features mild reaction conditions, simple operation, high-functional-group tolerance, facile scalability, and heterocycle compatibility.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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页数：4
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