Facile access to ?-hydroxyl ketones via a cobalt-catalyzed ring-opening/hydroxylation cascade of cyclopropanols

被引：5

作者：

Zhai, Shengxian ^{[1
]}

Qiu, Shuxian ^{[2
]}

Yang, Shuangtao ^{[1
]}

Gao, Xingyuan ^{[2
]}

Feng, Xinyu ^{[1
]}

Yun, Chenzhe ^{[1
]}

Han, Ning ^{[1
]}

Niu, Yongsheng ^{[1
]}

Wang, Jing ^{[1
]}

Zhai, Hongbin ^{[3
,4
,5
,6
]}

机构：

[1] Anyang Inst Technol, Coll Chem & Environm Engn, Anyang 455000, Peoples R China

[2] Guangdong Univ Educ, Engn Technol Dev Ctr Adv Mat & Energy Saving Emiss, Guangzhou 510303, Peoples R China

[3] Peking Univ, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[4] Peking Univ, Key Lab Chem Genom, Shenzhen Engn Lab Nano Drug Slow Release, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[5] Shenzhen Bay Lab, Shenzhen 518055, Peoples R China

[6] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2023年 / 34卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Cobalt catalysis; Ring-opening; Cyclopropanol; -Hydroxy ketone; Cascade reaction; C BOND-CLEAVAGE; EFFICIENT SYNTHESIS; H ACTIVATION; VINYL AZIDES; BETA; STRATEGY; FUNCTIONALIZATION; CHEMISTRY; TRIFLUOROMETHYLATION; FLUORINATION;

D O I：

10.1016/j.cclet.2022.06.080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cobalt-catalyzed ring-opening/hydroxylation cascade of highly strained cyclopropanols has been developed for the first time. The reaction was conducted under open-air atmosphere to afford a broad series of structurally diverse /3-hydroxy ketones in moderate to good yields with high regioselectivity. The protocol features mild reaction conditions, simple operation, high-functional-group tolerance, facile scalability, and heterocycle compatibility.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

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页数：4

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