Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors

被引：6
|
作者：
Dong, Fuxing [1 ,2 ]
Liu, Yaping [3 ]
Yan, Weixing [1 ]
Meng, Qiqi [1 ]
Song, Xueli [1 ]
Cheng, Bing [1 ]
Yao, Ruiqin [1 ]
机构：
[1] Xuzhou Med Univ, Dept Cell Biol & Neurobiol, Xuzhou Key Lab Neurobiol, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Public Expt Res Ctr, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Lab Natl Expt Teaching & Demonstrat Ctr Basic Med, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Netrin-4; Axon guidance; Angiogenesis; Tumor; DCC; Unc5; Neogenin; EPITHELIUM-DERIVED FACTOR; NF-KAPPA-B; CELL-PROLIFERATION; BREAST-CANCER; ANTITUMOR IMIDAZOTETRAZINES; DEPENDENCE RECEPTORS; MONOCLONAL-ANTIBODY; GENE-EXPRESSION; IDENTIFICATION; PROMOTES;
D O I：
10.1007/s10571-022-01279-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high correlation with the laminin beta-chain and promoted the growth of neurites in cultured olfactory bulb explants. Subsequently, it was discovered that Netrin-4 is involved in regulating various physiological processes, including angiogenesis, the occurrence and metastasis of various tumors, and the development of the kidney and alveoli. This paper reviews the current research on Netrin-4 since its discovery and provides a theoretical basis for further research on the biological characteristics of Netrin-4.
引用
收藏
页码：1663 / 1683
页数：21
相关论文
共 50 条
  • [41] The Role of the Cysteine-Rich Domain and Netrin-Like Domain of Secreted Frizzled-Related Protein 4 in Angiogenesis Inhibition In Vitro
    Longman, David
    Arfuso, Frank
    Viola, Helena M.
    Hool, Livia C.
    Dharmarajan, Arunasalam M.
    ONCOLOGY RESEARCH, 2012, 20 (01) : 1 - 6
  • [42] Percutaneous Radiofrequency Ablation of Small Renal Tumors Using CT-Guidance A Review and Its Current Role
    Haddad, Richard L.
    Patel, Manish I.
    Vladica, Philip
    Kassouf, Wassim
    Bladou, Frank
    Anidjar, Maurice
    UROLOGY JOURNAL, 2012, 9 (04) : 629 - 638
  • [43] Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors
    Mark Bischoff
    Gisela Bischoff
    Andreas Buck
    Alexandra von Baer
    Sandra Pauls
    Florian Scheffold
    Markus Schultheiss
    Florian Gebhard
    Sven N. Reske
    Archives of Orthopaedic and Trauma Surgery, 2010, 130 : 819 - 827
  • [44] Integrated FDG-PET-CT: its role in the assessment of bone and soft tissue tumors
    Bischoff, Mark
    Bischoff, Gisela
    Buck, Andreas
    von Baer, Alexandra
    Pauls, Sandra
    Scheffold, Florian
    Schultheiss, Markus
    Gebhard, Florian
    Reske, Sven N.
    ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2010, 130 (07) : 819 - 827
  • [45] Role of SEL1L in the progression of solid tumors, with a special focus on its recent therapeutic potential
    Darmadi, Darmadi
    Saleh, Raed Obaid
    Oghenemaro, Enwa Felix
    Shakir, Maha Noori
    Hjazi, Ahmed
    Hassan, Zahraa F.
    Zwamel, Ahmed Hussein
    Matlyuba, Sanoeva
    Deorari, Mahamedha
    Oudah, Shamam Kareem
    CELL BIOLOGY INTERNATIONAL, 2025, 49 (01) : 16 - 32
  • [46] Stability challenges not addressed by harmonized guidance – AAPS workshop of the stability focus group, April 3rd- 4th, 2017 in Rockville, MD
    Mohd M. Khan
    Bowen Jiang
    Anthony Mazzeo
    Kim Huynh-Ba
    AAPS Open, 4 (1)
  • [47] Regulation of EphA4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function
    Egea, J
    Nissen, UV
    Dufour, A
    Sahin, M
    Greer, P
    Kullander, K
    Mrsic-Flogel, TD
    Greenberg, ME
    Kiehn, O
    Vanderhaeghen, P
    Klein, R
    NEURON, 2005, 47 (04) : 515 - 528
  • [48] Vitamin B12 in Foods, Food Supplements, and Medicines-A Review of Its Role and Properties with a Focus on Its Stability
    Temova Rakusa, Zane
    Roskar, Robert
    Hickey, Neal
    Geremia, Silvano
    MOLECULES, 2023, 28 (01):
  • [49] Six-transmembrane Epithelial Antigen of Prostate 4 (Steap4) and its role in Diabetic Retinopathy Angiogenesis
    Howell, Scott J.
    Taylor, Brooklyn E.
    Lee, Chieh
    Taylor, Patricia R.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (07)
  • [50] eIF4E expression in tumors: its possible role in progression of malignancies
    De Benedetti, A
    Harris, AL
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1999, 31 (01): : 59 - 72
12345