Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors

被引：6
|
作者：
Dong, Fuxing [1 ,2 ]
Liu, Yaping [3 ]
Yan, Weixing [1 ]
Meng, Qiqi [1 ]
Song, Xueli [1 ]
Cheng, Bing [1 ]
Yao, Ruiqin [1 ]
机构：
[1] Xuzhou Med Univ, Dept Cell Biol & Neurobiol, Xuzhou Key Lab Neurobiol, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Public Expt Res Ctr, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Lab Natl Expt Teaching & Demonstrat Ctr Basic Med, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Netrin-4; Axon guidance; Angiogenesis; Tumor; DCC; Unc5; Neogenin; EPITHELIUM-DERIVED FACTOR; NF-KAPPA-B; CELL-PROLIFERATION; BREAST-CANCER; ANTITUMOR IMIDAZOTETRAZINES; DEPENDENCE RECEPTORS; MONOCLONAL-ANTIBODY; GENE-EXPRESSION; IDENTIFICATION; PROMOTES;
D O I：
10.1007/s10571-022-01279-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high correlation with the laminin beta-chain and promoted the growth of neurites in cultured olfactory bulb explants. Subsequently, it was discovered that Netrin-4 is involved in regulating various physiological processes, including angiogenesis, the occurrence and metastasis of various tumors, and the development of the kidney and alveoli. This paper reviews the current research on Netrin-4 since its discovery and provides a theoretical basis for further research on the biological characteristics of Netrin-4.
引用
收藏
页码：1663 / 1683
页数：21
相关论文
共 50 条
  • [21] Evidence for the coevolution of axon guidance molecule Netrin and its receptor Frazzled
    Huang, Ling
    Zhao, Xiao
    Yu, Qi
    Cui, Wei-Zheng
    Liu, Qing-Xin
    GENE, 2014, 544 (01) : 25 - 31
  • [22] Elevated Netrin-4 Expression and Its Action in Infrapatellar Fat Pad
    Uekusa, Yui
    Mukai, Manabu
    Tsukada, Ayumi
    Iwase, Dai
    Aikawa, Jun
    Shibata, Naoya
    Ohashi, Yoshihisa
    Inoue, Gen
    Takaso, Masashi
    Uchida, Kentaro
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (21)
  • [23] Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B
    Lejmi, Esma
    Leconte, Laurence
    Pedron-Mazoyer, Sandrine
    Ropert, Stanislas
    Raoul, William
    Lavalette, Sophie
    Bouras, Ilyes
    Feron, Jean-Guillaume
    Maitre-Boube, Martine
    Assayag, Franck
    Feumi, Charles
    Alemany, Monica
    Jie, Tan Xian
    Merkulova, Tatyana
    Poupon, Marie-France
    Ruchoux, Marie-Magdeleine
    Tobelem, Gerard
    Sennlaub, Florian
    Plouet, Jean
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (34) : 12491 - 12496
  • [24] Role of Netrin-4 and Laminin β2 and γ3 Chains in Corneal Development and Maintenance
    Martino, Jeremiah
    Bachay, Galina
    Dattilo, Michael
    Lazzaro, Douglas
    Brunken, William
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
  • [25] A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis
    Klagsbrun, M
    Eichmann, A
    CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (4-5) : 535 - 548
  • [26] Netrin-1: Focus on its role in cardiovascular physiology and atherosclerosis
    Claro, Vasco
    Ferro, Albert
    JRSM CARDIOVASCULAR DISEASE, 2020, 9
  • [27] DIFFERENTIAL EXPRESSION PATTERN OF THE RELATED GUIDANCE RECEPTORS NEOGENIN, UNC5B AND NEIGHBOR OF PUNC E11 AND THE GUIDANCE CUES NETRIN-1 AND NETRIN-4 IN DEVELOPING AND ADULT LIVER
    Sauer, Elisabeth
    Curth, Harald M.
    Odenthal, Margarefe
    Goeser, Tabias
    Nierhoff, Dirk
    HEPATOLOGY, 2009, 50 (04) : 757A - 757A
  • [28] The dual role of the ligand UNC-6/Netrin in both axon guidance and synaptogenesis in C. elegans
    Killeen, Marie T.
    CELL ADHESION & MIGRATION, 2009, 3 (03) : 268 - 271
  • [29] Serum Levels of Netrin-4 and Its Association With Hepatocellular Carcinoma: Results From a Case-Control Study
    Jyothi, Vennela
    Pottakkat, Biju
    Balasubramaniyan, V
    Verma, Surendra Kumar
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (08)
  • [30] Circulating Netrin-4 levels and influencing factors in women with PCOS and the role of anti-insulin resistance therapy
    Xue, S.
    Li, L.
    DIABETOLOGIA, 2024, 67 : S126 - S127
12345