Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors

被引：6
|
作者：
Dong, Fuxing [1 ,2 ]
Liu, Yaping [3 ]
Yan, Weixing [1 ]
Meng, Qiqi [1 ]
Song, Xueli [1 ]
Cheng, Bing [1 ]
Yao, Ruiqin [1 ]
机构：
[1] Xuzhou Med Univ, Dept Cell Biol & Neurobiol, Xuzhou Key Lab Neurobiol, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Public Expt Res Ctr, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Lab Natl Expt Teaching & Demonstrat Ctr Basic Med, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Netrin-4; Axon guidance; Angiogenesis; Tumor; DCC; Unc5; Neogenin; EPITHELIUM-DERIVED FACTOR; NF-KAPPA-B; CELL-PROLIFERATION; BREAST-CANCER; ANTITUMOR IMIDAZOTETRAZINES; DEPENDENCE RECEPTORS; MONOCLONAL-ANTIBODY; GENE-EXPRESSION; IDENTIFICATION; PROMOTES;
D O I：
10.1007/s10571-022-01279-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high correlation with the laminin beta-chain and promoted the growth of neurites in cultured olfactory bulb explants. Subsequently, it was discovered that Netrin-4 is involved in regulating various physiological processes, including angiogenesis, the occurrence and metastasis of various tumors, and the development of the kidney and alveoli. This paper reviews the current research on Netrin-4 since its discovery and provides a theoretical basis for further research on the biological characteristics of Netrin-4.
引用
收藏
页码：1663 / 1683
页数：21
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