Non-Viral Nucleic Acid Delivery System for RNA Therapeutics

被引：4
|
作者：
Liu, Lianxiao [1 ]
Zhou, Yiming [1 ]
Xu, Anqiu [1 ]
Wang, Chenglong [1 ]
Li, Ning [1 ]
Huang, Hongwei [1 ,2 ,3 ]
Zhang, Yuntao [4 ]
Yang, Xiaoming [4 ]
机构：
[1] China Natl Biol Grp Virogin Biotech Shanghai Ltd, CNBG Virogin, Shanghai 201802, Peoples R China
[2] Virogin Biotech Shanghai Ltd, Shanghai 201802, Peoples R China
[3] Virogin Biotech Canada Ltd, Richmond, ON V6V1A8, Canada
[4] China Natl Biotech Grp CNBG, Beijing 100024, Peoples R China
来源：
ADVANCED THERAPEUTICS | 2023年 / 6卷 / 08期
关键词：
drug delivery; gene therapy; nanotechnology; nucleic acid; vectors; RNA therapeutics; NEGATIVE BREAST-CANCER; LIPID NANOPARTICLES; DRUG-DELIVERY; MESSENGER-RNA; GENE DELIVERY; IN-VIVO; MEDIATED DELIVERY; SIRNA DELIVERY; ASIALOGLYCOPROTEIN RECEPTOR; TARGETED DELIVERY;
D O I：
10.1002/adtp.202300005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nucleic acid drugs can treat diseases caused by defective or abnormal genes. Herein, the mechanism of non-viral vectors for nucleic acid drug delivery is described. This review introduce non-viral vectors for nucleic acid drug delivery, including the nucleic acid-carrier conjugate, proteins and peptides-based nanoparticles, polysaccharides, and other biological macromolecules-based nanoparticles consisting of lipid nanoparticles, synthetic polymers-based nanoparticles, inorganic nanoparticles, and organic-inorganic hybrid nanoparticles. Finally, the challenges and prospects of non-viral vectors for nucleic acid drug delivery are discussed.
引用
收藏
页数：23
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