Non-Viral Nucleic Acid Delivery System for RNA Therapeutics

被引：4
|
作者：
Liu, Lianxiao [1 ]
Zhou, Yiming [1 ]
Xu, Anqiu [1 ]
Wang, Chenglong [1 ]
Li, Ning [1 ]
Huang, Hongwei [1 ,2 ,3 ]
Zhang, Yuntao [4 ]
Yang, Xiaoming [4 ]
机构：
[1] China Natl Biol Grp Virogin Biotech Shanghai Ltd, CNBG Virogin, Shanghai 201802, Peoples R China
[2] Virogin Biotech Shanghai Ltd, Shanghai 201802, Peoples R China
[3] Virogin Biotech Canada Ltd, Richmond, ON V6V1A8, Canada
[4] China Natl Biotech Grp CNBG, Beijing 100024, Peoples R China
来源：
ADVANCED THERAPEUTICS | 2023年 / 6卷 / 08期
关键词：
drug delivery; gene therapy; nanotechnology; nucleic acid; vectors; RNA therapeutics; NEGATIVE BREAST-CANCER; LIPID NANOPARTICLES; DRUG-DELIVERY; MESSENGER-RNA; GENE DELIVERY; IN-VIVO; MEDIATED DELIVERY; SIRNA DELIVERY; ASIALOGLYCOPROTEIN RECEPTOR; TARGETED DELIVERY;
D O I：
10.1002/adtp.202300005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nucleic acid drugs can treat diseases caused by defective or abnormal genes. Herein, the mechanism of non-viral vectors for nucleic acid drug delivery is described. This review introduce non-viral vectors for nucleic acid drug delivery, including the nucleic acid-carrier conjugate, proteins and peptides-based nanoparticles, polysaccharides, and other biological macromolecules-based nanoparticles consisting of lipid nanoparticles, synthetic polymers-based nanoparticles, inorganic nanoparticles, and organic-inorganic hybrid nanoparticles. Finally, the challenges and prospects of non-viral vectors for nucleic acid drug delivery are discussed.
引用
收藏
页数：23
相关论文
共 50 条
  • [11] Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics
    Van de Vyver, Thijs
    De Smedt, Stefaan C.
    Raemdonck, Koen
    ADVANCED DRUG DELIVERY REVIEWS, 2022, 181
  • [12] Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer
    Kanvinde, Shrey
    Kulkarni, Tanmay
    Deodhar, Suyash
    Bhattacharya, Deep
    Dasgupta, Aneesha
    BIOTECH, 2022, 11 (01):
  • [13] Editorial: Non-viral vectors for gene therapy/nucleic acid delivery
    Poddar, Arpita
    Banerjee, Rajkumar
    Shukla, Ravi
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 11
  • [14] Non-viral delivery of nucleic acid for treatment of rare diseases of the muscle
    Divya Rao
    Munia Ganguli
    Journal of Biosciences, 49
  • [15] Non-viral delivery of nucleic acid for treatment of rare diseases of the muscle
    Rao, Divya
    Ganguli, Munia
    JOURNAL OF BIOSCIENCES, 2024, 49 (01)
  • [16] Polyethylenimine: A versatile, multifunctional non-viral vector for nucleic acid delivery
    Pandey, Abhijeet P.
    Sawant, Krutika K.
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 68 : 904 - 918
  • [17] Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines
    Deering, Raquel P.
    Kommareddy, Sushma
    Ulmer, Jeffrey B.
    Brito, Luis A.
    Geall, Andrew J.
    EXPERT OPINION ON DRUG DELIVERY, 2014, 11 (06) : 885 - 899
  • [18] Aerosolized Non-viral Nucleic Acid Delivery in the Vaginal Tract of Pigs
    Remaut, Katrien
    De Clercq, Evelien
    Andries, Oliwia
    Rombouts, Koen
    Van Gils, Matthias
    Cicchelero, Laetitia
    Vandenbussche, Ian
    Van Praet, Sarah
    Benito, Juan Manuel
    Fernandez, Jose Manuel Garcia
    Sanders, Niek
    Vanrompay, Daisy
    PHARMACEUTICAL RESEARCH, 2016, 33 (02) : 384 - 394
  • [19] Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions
    Elsabahy, Mahmoud
    Nazarali, Adil
    Foldvari, Marianna
    CURRENT DRUG DELIVERY, 2011, 8 (03) : 235 - 244
  • [20] Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
    Wang, Yanfang
    Wagner, Ernst
    PHARMACEUTICS, 2020, 12 (09) : 1 - 31
12345