Flavonoid Diglycosides from Dendrobium officinale Leaves and Their Tyrosinase Inhibitory Activity

被引：1

作者：

Chen, Yi-Fang ^{[1
,2
,3
,4
]}

Luo, Ji-Feng ^{[3
,4
]}

Zhang, Yan-Ni ^{[1
,2
]}

Wang, Yue-Hu ^{[3
,4
]}

机构：

[1] Shaanxi Normal Univ, Natl Engn Lab Resource Dev Endangered Crude Drugs, Key Lab Med Resources & Nat Pharmaceut Chem, Minist Educ, Xian 710119, Peoples R China

[2] Shaanxi Normal Univ, Sch Life Sci, Xian 710119, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 06期

关键词：

Orchidaceae; Dendrobium officinale; flavonoid diglycosides; C-glycosides; tyrosinase inhibitory activity; GLYCOSIDES;

D O I：

10.1007/s10600-023-04198-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four flavonoid C-glycosides, including two new diglycosides, dendrodiglycosides A (1) and B (2), along with known isoviolanthin (3) and apigenin 6-C-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside (4), were isolated from the leaves of Dendrobium officinale (Orchidaceae). Their structures were elucidated by NMR and MS. Apigenin 6-C-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside exhibited an inhibitory effect against tyrosinase with an IC50 value of 146.5 mu g/mL.

引用

页码：1067 / 1074

页数：8

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