Synthesis of oligonucleotides containing 5′-homo-4′-selenouridine derivative and its increased resistance against nuclease

被引：1

作者：

Yu, Jinha ^{[1
,2
,3
]}

Kim, Ji Won ^{[1
]}

Chandra, Girish ^{[1
,4
]}

Saito-Tarashima, Noriko ^{[5
]}

Nogi, Yuhei ^{[5
]}

Ota, Masashi ^{[5
]}

Minakawa, Noriaki ^{[5
]}

Jeong, Lak Shin ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea

[2] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea

[3] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea

[4] Cent Univ South Bihar, Gaya 824236, Bihar, India

[5] Tokushima Univ, Grad Sch Pharmaceut Sci, Shomachi 1-78-1, Tokushima 7708505, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 83卷

基金：

新加坡国家研究基金会;

关键词：

5 '-Homo-4 '-Selenonucleoside; Oligonucleotide; Nuclease resistance; Thermostability; 1ST SYNTHESIS; ANTISENSE; HYBRIDIZATION;

D O I：

10.1016/j.bmcl.2023.129172

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As technologies using RNA or DNA have been developed, various chemical modifications of nucleosides have been attempted to increase the stability of oligonucleotides. Since it is known that 2 '-OMe-modification greatly contributes to increasing the stability of oligonucleotides, we added 2 '-OMe to our previously developed 4 '-selenonucleoside and 5 '-homo-4 '-selenonucleoside as the modified monomers for oligonucleotide: 2 '-methoxy-4 '-selenouridine (2 '-OMe-4 '-Se-U) and 5 '-homo-2 '-methoxy-4 '-selenouridine (5 '-homo-2 '-OMe-4 '-Se-U). We synthesized oligonucleotides containing the chemically modified 4 '-selenouridine and evaluated their thermal stability and nuclease resistance. In conclusion, the nuclease stability of the oligonucleotide containing 5 '-homo-2 '-OMe-4 '-selenouridine increased while its thermal stability decreased.

引用

页数：5

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