ER stress modulates the immune regulatory ability in gut M2 cells of patients with ulcerative colitis

被引：4

作者：

Feng, Baisui ^{[1
]}

Xu, Lingzhi ^{[2
]}

Song, Shuo ^{[3
,4
]}

Liu, Huazhen ^{[3
,4
]}

Li, Yan ^{[1
]}

Hu, Suqin ^{[3
,4
]}

Shu, Qing ^{[5
]}

Liu, Jiangqi ^{[6
]}

Liu, Zhiqiang ^{[6
]}

Yu, Haiqiong ^{[7
]}

Yang, Pingchang ^{[3
,4
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 2, Dept Gastroenterol, Zhengzhou, Peoples R China

[2] Weifang Med Univ, Sch Basic Med Sci, Dept Immunol, Weifang, Peoples R China

[3] Guangdong Prov Reg Dis Key Lab, Shenzhen, Peoples R China

[4] Shenzhen Univ, State Key Lab Resp Dis Div Shenzhen Univ, Inst Allergy & Immunol, Shenzhen, Peoples R China

[5] Shenzhen Second Peoples Hosp, Dept Gastroenterol, Shenzhen, Peoples R China

[6] Longgang ENT Hosp, Dept Allergy, Shenzhen, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Pulm & Crit Care Med, Shenzhen 518033, Peoples R China

来源：

ISCIENCE | 2023年 / 26卷 / 04期

基金：

中国国家自然科学基金;

关键词：

CORTICOSTEROID RESISTANCE; MACROPHAGE POLARIZATION; CROHNS-DISEASE;

D O I：

10.1016/j.isci.2023.106498

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aims to characterize the impaired immune regulatory function of M4 obtained from UC patient colon lavage fluid (CLF). M4s were the largest proportion (21.3 4.0%) of the CLF-derived cellular components. Less abundant and weaker immune suppressive function were observed in M2 M4s (M2 cells) of the ulcerative colitis (UC) group. High levels of endoplasmic reticulum (ER) stress associated molecules were detected in UC M2 cells. The spliced X box binding protein-1 (XBP1) gene was negatively correlated with programmed death ligand-1 (PD-L1) in UC M2 cells. XBP1 promoted the expression of ring-finger protein 20 (Rnf20) in M2 cells. Rnf20 reduced PD-L1 abundance in UC M2 cells and impaired the immune suppressive ability. Inhibition of Rnf20 restored the immune regulating capacity of M2 cells and suppressed experimental colitis.

引用

页数：18

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