In this paper, we get some new properties of the weighted Radon transform by Fourier transform, convolution, Riesz potential, and so on. Meanwhile, the results of Natterer are generalized to non-uniform attenuation. Furthermore we study the Sobolev estimation of the n-dimensional non-uniform attenuation Radon transform and its dual operator by the Young's inequality. Then, we extend conclusions of Rigaud and Lakhal to the n-dimensional space. Finally, the results of Sharafutdinov are generalized to non-uniform attenuation.