1,2,4-Thiadiazole alkaloids - Isolation, biological activity and synthesis

被引：2
|
作者：
Anstis, Daniel G. [1 ]
Davison, Emma K. [1 ,2 ]
Sperry, Jonathan [1 ]
机构：
[1] Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland, New Zealand
[2] Cloudburst Biotech, 8999 Nelson Way, Burnaby, BC V5A1S6, Canada
来源：
TETRAHEDRON | 2024年 / 150卷
关键词：
AUSTRALIAN MARINE SPONGE; NATURAL-PRODUCTS; BIOSYNTHESIS; DERIVATIVES; INHIBITORS; ACID; RING; CEPHALOSPORIN; ROOT;
D O I：
10.1016/j.tet.2023.133767
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Natural products with heteroatom rich ring systems are aesthetically pleasing molecules that provide a platform for innovation in synthetic heterocyclic chemistry. Herein, we discuss one subset of these natural products, the 1,2,4-thiadiazoles. Alongside their isolation and biological activity, fascinating biosynthesis proposals are also provided. All the known 1,2,4-thiadiazole alkaloids have succumbed to synthesis, leading to advances in heterocyclic chemistry and biomimetic synthesis.
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页数：8
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