A New, Ecological and Stability-indicating Method by HPLC for the Quantification of Moxifloxacin in Tablets

被引：3
|
作者：
da Silva, Thaisa Alves Celedonio [1 ]
da Silva Junior, Joao Roberto [1 ]
Kogawa, Ana Carolina [1 ]
机构：
[1] Univ Fed Goias, Fac Farm, Dept Pharm, Lab Controle Qualidade, Rua 240,S-N,Setor Leste Univ, BR-74605170 Goiania, GO, Brazil
来源：
CURRENT GREEN CHEMISTRY | 2023年 / 10卷 / 02期
关键词：
HPLC; green analytical chemistry; method validation; tablets; fluoroquinolone; moxifloxacin; GREEN;
D O I：
10.2174/2213346110666230331085433
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33 degrees C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin(-1), injection volume of 5 mu L, and detection at 290 nm was used. Methods: The method was linear (2-12 mu gmL(-1)), selective, accurate (100.86%), precise (RSD<2%), and robust. Results: The retention time for moxifloxacin in tablets was approximately 4.4 minutes. Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.
引用
收藏
页码：165 / 173
页数：9
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