A New, Ecological and Stability-indicating Method by HPLC for the Quantification of Moxifloxacin in Tablets

Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33 degrees C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin(-1), injection volume of 5 mu L, and detection at 290 nm was used. Methods: The method was linear (2-12 mu gmL(-1)), selective, accurate (100.86%), precise (RSD<2%), and robust. Results: The retention time for moxifloxacin in tablets was approximately 4.4 minutes. Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.